Zhou Tiantian, Cheng Bei, Gao Lumin, Ren Fengyun, Guo Guanglun, Wassie Teketay, Wu Xin
CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, China.
Hunan Co-Innovation Center of Safety Animal Production, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
Front Vet Sci. 2022 Nov 23;9:1014313. doi: 10.3389/fvets.2022.1014313. eCollection 2022.
As a crucial antioxidant enzyme, catalase (CAT) could destroy the cellular hydrogen peroxide to mitigate oxidative stress. The current study aimed to investigate the effects of maternal CAT supplementation from late gestation to day 14 of lactation on antioxidant ability and fatty acids metabolism with regard to the sow-piglet-axis. On day 95 of gestation, forty sows were divided into control (CON) group (fed a basal diet) and CAT group (fed a basal diet supplemented with 660 mg/kg CAT), the feeding experiment ended on day 14 of lactation.
The lactating sows in the CAT group produced more milk, and had higher antioxidant enzymes activity including POD and GSH-Px ( < 0.05), lower content of serum LDL as well as plasmic C18:3n3 content ( < 0.05). Additionally, maternal CAT supplementation improved offspring's body weight at day 14 of nursing period and ADG ( < 0.05), and regulated the antioxidant ability as evidenced by decreased related enzymes activity such as T-AOC and CAT and changed genes expression level. It significantly affected lipid metabolism of suckling piglets manifested by increasing the serum ALT, CHOL, and LDL ( < 0.05) level and modulating plasma medium- and long-chain fatty acids (MCFAs and LCFAs), as well as regulating the genes expression involved in lipid metabolism.
Maternal CAT supplementation could regulate the fatty acid composition and enhance the antioxidant ability of sows and offspring during the lactating period and further promote the growth of suckling piglets. These findings might provide a reference value for the utilization of CAT as supplement for mother from late pregnancy to lactation period to promote the fatty acid metabolism of offspring.
过氧化氢酶（CAT）作为一种关键的抗氧化酶，可分解细胞内的过氧化氢以减轻氧化应激。本研究旨在探讨妊娠后期至哺乳期第14天母猪补充CAT对母猪-仔猪轴抗氧化能力和脂肪酸代谢的影响。在妊娠第95天，将40头母猪分为对照组（CON，饲喂基础日粮）和CAT组（饲喂添加660 mg/kg CAT的基础日粮），饲养试验在哺乳期第14天结束。
CAT组哺乳母猪产奶量更高，抗氧化酶活性（包括POD和GSH-Px）更高（P<0.05），血清低密度脂蛋白（LDL）含量以及血浆C18:3n3含量更低（P<0.05）。此外，母猪补充CAT可提高哺乳期第14天仔猪体重和平均日增重（ADG）（P<0.05），并通过降低T-AOC和CAT等相关酶活性以及改变基因表达水平来调节抗氧化能力。它对哺乳仔猪脂质代谢有显著影响，表现为血清谷丙转氨酶（ALT）、胆固醇（CHOL）和LDL水平升高（P<0.05），调节血浆中、长链脂肪酸（MCFAs和LCFAs），以及调节参与脂质代谢的基因表达。
母猪补充CAT可调节哺乳期母猪和仔猪的脂肪酸组成，增强其抗氧化能力，并进一步促进哺乳仔猪生长。这些发现可能为在妊娠后期至哺乳期利用CAT作为母体补充剂以促进后代脂肪酸代谢提供参考价值。
