Shen Yong, Wan Haifeng, Zhu Jiatao, Fang Zhengfeng, Che Lianqiang, Xu Shengyu, Lin Yan, Li Jian, Wu De
Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture of China, Institute of Animal Nutrition, Sichuan Agricultural University, Ya'an, 625014, Sichuan, China,
Lipids. 2015 Jul;50(7):647-58. doi: 10.1007/s11745-015-4024-x. Epub 2015 May 13.
This study was conducted to compare the effects of fish oil and olive oil supplementation in late pregnancy and during lactation on oxidative stress and inflammation in sows and their piglets. A total of 24 sows were fed a basal diet supplemented with additional corn starch (CON), fish oil (FO) or olive oil (OO). Sows fed an OO diet during late gestation had a higher piglet birth weight compared with CON-fed and FO-fed sows (P < 0.05). Furthermore, sows from the OO group had a higher milk fat content than sows from CON and FO groups, and a lower pre-weaning mortality of piglets was observed in the OO group (P < 0.05). Maternal FO supplementation resulted in increased malondialdehyde concentration in sow plasma, colostrum, milk and piglet plasma than in CON and OO groups (P < 0.05). However, an increased total antioxidant capacity (T-ACC) and activities of glutathione peroxidase (GSH-Px) and total superoxide dismutase (T-SOD) were also observed in the FO group (P < 0.05). Sows fed an OO diet had significantly decreased interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations in milk compared with CON and FO fed sows (P < 0.05). Moreover, lower plasma IL-1β and TNF-α levels were observed in piglets from the OO group compared with the CON group (P < 0.05). Collectively, these results suggest that an OO diet is most beneficial in late gestation and during lactation in sows. However, FO increases the susceptibility to oxidative stress in sows and piglets.
本研究旨在比较妊娠后期和哺乳期补充鱼油和橄榄油对母猪及其仔猪氧化应激和炎症的影响。总共24头母猪被饲喂添加了额外玉米淀粉（CON）、鱼油（FO）或橄榄油（OO）的基础日粮。与饲喂CON日粮和FO日粮的母猪相比，妊娠后期饲喂OO日粮的母猪所产仔猪出生体重更高（P<0.05）。此外，OO组母猪的乳脂含量高于CON组和FO组母猪，并且OO组仔猪断奶前死亡率较低（P<0.05）。与CON组和OO组相比，母体补充FO导致母猪血浆、初乳、乳汁和仔猪血浆中丙二醛浓度升高（P<0.05）。然而，FO组中还观察到总抗氧化能力（T-ACC）以及谷胱甘肽过氧化物酶（GSH-Px）和总超氧化物歧化酶（T-SOD）活性增加（P<0.05）。与饲喂CON日粮和FO日粮的母猪相比, 饲喂OO日粮的母猪乳汁中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）浓度显著降低（P<0.05）。此外，与CON组相比，OO组仔猪血浆中IL-1β和TNF-α水平较低（P<0.05）。总体而言，这些结果表明，OO日粮对母猪妊娠后期和哺乳期最为有益。然而，FO会增加母猪和仔猪对氧化应激的易感性。
