Zhang Xiaochang, Li Wei, Liu Yonghua, Xu Linglong, Wang Xu, Feng Xiaoning
Department of Hematology and Oncology, Taizhou Central Hospital (Taizhou University Hospital) Taizhou 318000, Zhejiang, P. R. China.
Cancer and Stem Cell Center, First Affiliated Hospital, Jilin University Changchun 130061, Jilin, P. R. China.
Am J Transl Res. 2022 Nov 15;14(11):7771-7781. eCollection 2022.
To assess the value of plasma vitamin D level and nomogram model in predicting the prognosis of patients with small cell lung cancer (SCLC) treated with platinum plus etoposide (PPE) as first-line chemotherapy.
In this retrospective study, we included 178 patients with SCLC. The data of 25(OH)D level, basic clinical information, overall survival (OS) and progression-free survival (PFS) were collected. Moreover, a nomogram was constructed to predict the prognosis of the patients.
The median OS value for patients with 25(OH)D < 10 ng/mL was 12.5 months. The median PFS value was 6.6 months. Sex, smoking status, clinical stage, and plasma vitamin D were independent prognostic predictors. Besides, the decision curve analysis and receiver operating characteristic curve indicated that the nomogram prediction models showed positive clinical benefit.
The plasma vitamin D level is of great significance in prognosis of patients with SCLC. The construction of nomograms is beneficial in predicting the prognosis of patients with SCLC treated with PPE.
评估血浆维生素D水平和列线图模型在预测接受铂类联合依托泊苷（PPE）作为一线化疗的小细胞肺癌（SCLC）患者预后中的价值。
在这项回顾性研究中，我们纳入了178例SCLC患者。收集了25(OH)D水平、基本临床信息、总生存期（OS）和无进展生存期（PFS）的数据。此外，构建了一个列线图来预测患者的预后。
25(OH)D<10 ng/mL患者的中位OS值为12.5个月。中位PFS值为6.6个月。性别、吸烟状况、临床分期和血浆维生素D是独立的预后预测因素。此外，决策曲线分析和受试者工作特征曲线表明列线图预测模型显示出积极的临床益处。
血浆维生素D水平对SCLC患者的预后具有重要意义。列线图的构建有助于预测接受PPE治疗的SCLC患者的预后。
