Department of Respiratory Medicine, University of Occupational and Environmental Health, Kitakyushu City, Japan.
Thorac Cancer. 2022 Aug;13(15):2279-2282. doi: 10.1111/1759-7714.14559. Epub 2022 Jun 28.
A 69-year-old Japanese man visited our hospital because of worsening shortness of breath. His chest computed tomography (CT) showed a giant left lung mass with a massive left pleural effusion. He could not be treated with chemotherapy and eventually died from a rapidly progressive tumor. He was diagnosed with combined small cell lung carcinoma (C-SCLC) with spindle-shaped cell tumor at autopsy. C-SCLC is characterized by pathologically concurrent SCLC and adenocarcinoma or squamous cell carcinoma, or rarely, spindle-shaped cell tumor. The clinical course of C-SCLC with spindle-shaped cell tumor has not previously been determined. Our patient's tumor increased by 2.59-fold in 20 days. The combination of C-SCLC with spindle-shaped cell tumor suggested rapid progression and a poor prognosis.
一位 69 岁的日本男性因呼吸困难加重而到我院就诊。他的胸部计算机断层扫描（CT）显示左肺巨大肿块伴大量左侧胸腔积液。他不能接受化疗治疗，最终因肿瘤快速进展而死亡。尸检诊断为小细胞肺癌合并梭形细胞肿瘤（C-SCLC）。C-SCLC 的特征是病理上同时存在小细胞肺癌和腺癌或鳞状细胞癌，或很少见的梭形细胞肿瘤。C-SCLC 伴梭形细胞肿瘤的临床病程以前尚未确定。我们患者的肿瘤在 20 天内增加了 2.59 倍。C-SCLC 伴梭形细胞肿瘤提示快速进展和预后不良。
