三氯生的耳毒性：一项大鼠模型研究。
Ototoxicity of Triclosan: A Rat Model Study.
作者信息
Günebakan Çağlar, Kahveci Orhan K, Kuzu Selçuk, Kandır Emine H
机构信息
Otolaryngology - Head and Neck Surgery, Afyonkarahisar Health Sciences University, Afyonkarahisar, TUR.
Faculty of Veterinary Medicine, Department of Wildlife and Ecology, Afyon Kocatepe University, Afyonkarahisar, TUR.
出版信息
Cureus. 2022 Dec 4;14(12):e32189. doi: 10.7759/cureus.32189. eCollection 2022 Dec.
OBJECTIVE
Triclosan is utilized as an antibacterial factor in many industrial products. Although there are many toxic features of triclosan in the literature, there is no study on the effect of triclosan on hearing. The purpose of this study is to determine the effect of triclosan on hearing in rats.
METHODS
In this prospective, experimental animal study, 40 healthy Sprague-Dawley rats with normal response to the distortion-product otoacoustic emission (DPOAE) measurements were divided into four groups. Group 1, as the control group, was given only corn oil, group 2 was given 5 mg/kg triclosan dissolved in corn oil, group 3 was given 10 mg/kg triclosan dissolved in corn oil, and group 4 was given 100 mg/kg triclosan dissolved in corn oil; triclosan and corn oil were administered by oral gavage to all groups.
RESULTS
In our study, low-dose triclosan did not cause hearing loss, but hearing loss was observed in the group that was given high-dose triclosan (100 mg/kg).
CONCLUSION
These findings suggest that triclosan causes hearing loss in rats. This issue should be investigated further to avoid triclosan ototoxicity in humans.
目的
三氯生在许多工业产品中用作抗菌因子。尽管文献中有许多关于三氯生毒性的描述，但尚无关于三氯生对听力影响的研究。本研究的目的是确定三氯生对大鼠听力的影响。
方法
在这项前瞻性实验动物研究中，将40只对畸变产物耳声发射（DPOAE）测量反应正常的健康Sprague-Dawley大鼠分为四组。第1组作为对照组，仅给予玉米油；第2组给予溶于玉米油的5mg/kg三氯生；第3组给予溶于玉米油的10mg/kg三氯生；第4组给予溶于玉米油的100mg/kg三氯生；所有组均通过灌胃给予三氯生和玉米油溶液和玉米油。
结果
在我们的研究中，低剂量三氯生未导致听力损失，但在给予高剂量三氯生（100mg/kg）的组中观察到了听力损失。
结论
这些发现表明三氯生会导致大鼠听力损失。应进一步研究此问题，以避免三氯生对人类产生耳毒性。
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