韩国年轻女性中与体重过轻、超重及饮食失调相关的生化、血液学和骨骼特征：一项基于人群的研究。
Biochemical, hematologic, and skeletal features associated with underweight, overweight, and eating disorders in young Korean women: A population-based study.
作者信息
An Zhen, Kim Kyung-Hee, Kim Mirihae, Kim Youl-Ri
机构信息
Institute of Eating Disorders and Mental Health, Inje University, Seoul, South Korea.
Department of Food and Nutrition, Duksung Women's University, Seoul, South Korea.
出版信息
Front Psychiatry. 2022 Nov 25;13:941043. doi: 10.3389/fpsyt.2022.941043. eCollection 2022.
BACKGROUND
Extreme weight conditions in young women are associated with adverse health outcomes. Closely linked with extreme weight status, eating disorders (EDs) are associated with several medical complications and high mortality rates.
OBJECTIVE
The study aimed to investigate the biochemical, hematologic, and skeletal features of young Korean women with underweight (UW) and overweight/obesity (OW) conditions, and patients with anorexia nervosa (AN) and bulimia nervosa (BN) compared to women with normal-weight (NW).
METHOD
A total of 808 women (mean age 22.3 ± 3.4 years) were recruited for the study, including 144 with UW status [body mass index (BMI) < 18.5 kg/m], 364 with NW, 137 with OW or obesity (27 with obesity; BMI ≥ 25 kg/m), 63 patients with anorexia nervosa (AN), and 100 with bulimia nervosa (BN). We measured blood pressure and performed biochemical, hematologic and bone mineral density (BMD) evaluations at the lumbar and femoral neck.
RESULTS
Blood pressure and triiodothyronine levels were found to be lower in both ED groups and higher in the OW group, but no difference in the UW group, compared to the NW group. The aminotransferases and total cholesterol levels were higher in the ED and OW groups, compared to the NW group. Blood cell counts were decreased in the AN group, while increased in the OW group, compared to the NW group. Blood urea nitrogen was elevated in both ED groups. The UW and AN groups had lower BMD, whereas the OW group had higher BMD, compared to the NW group.
CONCLUSION
Our findings suggested that both ED groups were associated with decreases in the resting energy expenditure. OW status was associated with a risk of metabolic syndrome, and UW status with lower BMD in young women. Overall, the medical parameters in Korean patients with ED were similar to the patterns reported in Western samples in previous studies, with few exceptions such as potassium level in BN.
背景
年轻女性的极端体重状况与不良健康后果相关。饮食失调（EDs）与极端体重状况密切相关，与多种医学并发症和高死亡率相关。
目的
本研究旨在调查体重过轻（UW）和超重/肥胖（OW）的年轻韩国女性以及神经性厌食症（AN）和神经性贪食症（BN）患者与正常体重（NW）女性相比的生化、血液学和骨骼特征。
方法
共招募了808名女性（平均年龄22.3±3.4岁）参与研究，其中144人体重过轻[体重指数（BMI）<18.5kg/m]，364人正常体重，137人超重或肥胖（27人肥胖；BMI≥25kg/m），63名神经性厌食症患者（AN），100名神经性贪食症患者（BN）。我们测量了血压，并对腰椎和股骨颈进行了生化、血液学和骨密度（BMD）评估。
结果
与NW组相比，两个ED组的血压和三碘甲状腺原氨酸水平较低，OW组较高，但UW组无差异。与NW组相比，ED组和OW组的转氨酶和总胆固醇水平较高。与NW组相比，AN组血细胞计数减少，而OW组增加。两个ED组的血尿素氮均升高。与NW组相比，UW组和AN组的骨密度较低，而OW组的骨密度较高。
结论
我们的研究结果表明，两个ED组均与静息能量消耗降低有关。OW状态与代谢综合征风险相关，UW状态与年轻女性较低的骨密度相关。总体而言，韩国ED患者的医学参数与先前研究中西方样本报道的模式相似，少数例外情况如BN中的钾水平。
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