Kobayashi Shunsuke, Yasu Takeo, Tagawa Seiji, Ogura Takashi, Kitaoka Akira, Matsubara Masaaki
Nissan Tamagawa Hospital, Department of Pharmacy, Tokyo, Japan.
Meiji Pharmaceutical University, Department of Medicinal Therapy Research, Pharmaceutical Education and Research Center, Tokyo, Japan.
Acta Ortop Bras. 2022 Dec 2;30(spe2):e248417. doi: 10.1590/1413-785220223002e248417. eCollection 2022.
Perioperative deep prosthetic joint infection (PJI) is a serious postoperative complication of total hip arthroplasty (THA). We aimed to compare the efficacy of cefazolin administered within 24 and 48 h of primary THA for PJI prophylaxis.
In this retrospective study, 720 patients were divided into two groups depending on whether cefazolin was administered as a single injection of 2 g twice daily within 24 (24-h group) or 48 h of surgery and the following day (48-h group). Sex, age at surgery, body mass index, co-existing diseases, blood test data, and PJI risk factors were evaluated.
The 24- and 48-h groups included 364 and 356 patients, respectively. Diabetes mellitus was the most common risk factor for PJI in both groups. The corresponding incidence of perioperative deep PJI following primary THA was 0.55% and 0.28% in the 24- and 48-h groups, respectively. There was no significant difference in patient background characteristics between the groups.
Cefazolin administration within 24 h of primary THA may be appropriate for perioperative deep PJI. .
围手术期深部假体关节感染（PJI）是全髋关节置换术（THA）严重的术后并发症。我们旨在比较初次全髋关节置换术（THA）术后24小时内和48小时内给予头孢唑林预防PJI的效果。
在这项回顾性研究中，720例患者根据头孢唑林是在手术24小时内（24小时组）还是48小时内及术后次日每日单次注射2克分为两组（48小时组）。评估了性别、手术年龄、体重指数、并存疾病、血液检测数据和PJI危险因素。
24小时组和48小时组分别包括364例和356例患者。糖尿病是两组中PJI最常见的危险因素。初次全髋关节置换术后围手术期深部PJI的相应发生率在24小时组和48小时组分别为0.55%和0.28%。两组患者背景特征无显著差异。
初次全髋关节置换术（THA）术后24小时内给予头孢唑林可能适用于围手术期深部PJI。
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