Lim Butaek, Kim Jinyeong, Desai Malav S, Wu Weiyu, Chae Inseok, Lee Seung-Wuk
Department of Bioengineering, University of California, Berkeley, Berkeley, California94720, United States.
Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California94720, United States.
Biomacromolecules. 2023 Jan 9;24(1):118-131. doi: 10.1021/acs.biomac.2c00957. Epub 2022 Dec 12.
Protein-based material design provides great advantages to developing smart biomaterials with tunable structures and desired functions. They have been widely used in many biomedical applications including tissue engineering and drug delivery. However, protein-based materials are not yet widely used in optoelectronic materials despite their excellent optical and tunable mechanical properties. Here, we synthesized engineered fluorescent proteins (FPs) fused with elastic protein for the development of optoelectrical down-converting optical filters for flexible display materials. We synthesized sequence-specific FPs to tune blue, green, yellow, and red colors and fused them with elastic protein to tune mechanical properties. We fabricated flexible self-supporting film materials and characterized mechanical properties and down-converting optical properties. We also fabricated a hybrid light-emitting diode (LED) to down convert blue to desired green, red, and white colors. Furthermore, we constructed a flexible white LED using organic LED as a flexible substrate. Our modular synthesis approach of tunable bio-optoelectrical material approaches will be useful to design future biocompatible and flexible display materials and technologies.
基于蛋白质的材料设计为开发具有可调节结构和所需功能的智能生物材料提供了巨大优势。它们已广泛应用于包括组织工程和药物递送在内的许多生物医学应用中。然而,尽管基于蛋白质的材料具有优异的光学和可调节的机械性能,但它们尚未广泛应用于光电子材料中。在此,我们合成了与弹性蛋白融合的工程荧光蛋白(FPs),用于开发用于柔性显示材料的光电下转换光学滤光片。我们合成了序列特异性FPs来调节蓝色、绿色、黄色和红色,并将它们与弹性蛋白融合以调节机械性能。我们制备了柔性自支撑薄膜材料,并对其机械性能和下转换光学性能进行了表征。我们还制造了一种混合发光二极管(LED),将蓝色下转换为所需的绿色、红色和白色。此外,我们使用有机LED作为柔性基板构建了柔性白色LED。我们这种可调节生物光电材料的模块化合成方法将有助于设计未来的生物相容性和柔性显示材料及技术。