Nasiri Farzad, Ellard Kristen K, Mashhadi Ali, Bigdeli Imanollah, Ghanaei-Chamanabad Ali
Department of psychology, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj, Iran.
Department of Psychology, Faculty of Educational Sciences and Psychology, Ferdowsi University of Mashhad, Mashhad, Iran.
Clin Psychol Psychother. 2023 Mar;30(2):446-457. doi: 10.1002/cpp.2812. Epub 2022 Dec 21.
The aim of the current study was to compare the unified protocol for transdiagnostic treatment of emotional disorders (UP) with and without transcranial direct current stimulation (tDCS) for the treatment of emotion regulation and executive control dysfunction in individuals diagnosed with generalized anxiety disorder (GAD) and comorbid major depressive disorder (MDD). A total of 43 individuals with GAD and co-morbid MDD were randomly assigned to three groups including UP with tDCS (UP+tDCS; n = 15), UP alone (UP; n = 13) or wait-list control (n = 15). Difficulties in emotion regulation, reappraisal, suppression, inhibition and working memory were assessed at baseline, post-treatment and 3-month follow-up. Treatment with both UP+tDCS and UP alone resulted in significant improvements in difficulties in emotion regulation, cognitive reappraisal, and working memory, and significant reductions in suppression and inhibition relative to wait-list controls at post-treatment and 3-month follow-up. Relative to UP alone, UP+tDCS showed significantly greater improvements in difficulties in emotion regulation, cognitive reappraisal, inhibition, and working memory at post-treatment and 3-month follow-up. These results suggest combination of UP treatment with tDCS may be an efficacious intervention to improve emotion regulation and executive function in GAD with co-morbid MDD. Trial registration reference is IRCT20140929019334N1 (see https://irct.ir/trial/27988).
本研究的目的是比较统一的情绪障碍跨诊断治疗方案（UP）联合与不联合经颅直流电刺激（tDCS）对诊断为广泛性焦虑症（GAD）合并重度抑郁症（MDD）的个体情绪调节和执行控制功能障碍的治疗效果。共有43名患有GAD合并MDD的个体被随机分配到三组，包括UP联合tDCS组（UP+tDCS；n = 15）、单纯UP组（UP；n = 13）或等待名单对照组（n = 15）。在基线、治疗后和3个月随访时评估情绪调节、重新评价、抑制、抑制控制和工作记忆方面的困难。与等待名单对照组相比，UP+tDCS组和单纯UP组在治疗后和3个月随访时，情绪调节困难、认知重新评价和工作记忆方面均有显著改善，抑制和抑制控制方面显著降低。与单纯UP组相比，UP+tDCS组在治疗后和3个月随访时，情绪调节困难、认知重新评价、抑制控制和工作记忆方面的改善更为显著。这些结果表明，UP治疗联合tDCS可能是改善GAD合并MDD患者情绪调节和执行功能的有效干预措施。试验注册参考号为IRCT20140929019334N1（见https://irct.ir/trial/27988）。
