氮杂环丙烷的催化对映选择性去对称化反应
Catalytic enantioselective desymmetrization of -aziridines.
作者信息
Yang Pei-Jun, Chai Zhuo
机构信息
Anhui Province Key Laboratory of Functional Coordinated Complexes for Materials Chemistry and Application, School of Chemical and Environmental Engineering, Anhui Polytechnic University, Middle Beijing Road, Wuhu, Anhui 241000, China.
MOE Key Laboratory of Functional Molecular Solids, Anhui Laboratory of Molecule-Based Materials, Institute of Organic Chemistry, College of Chemistry and Materials Science, Anhui Normal University, 189 South Jiuhua Road, Wuhu, Anhui 241002, China.
出版信息
Org Biomol Chem. 2023 Jan 18;21(3):465-478. doi: 10.1039/d2ob01935c.
As a type of readily available small strained-ring heterocycle, -aziridines may undergo catalytic desymmetrizing transformations to empower the rapid construction of diverse nitrogen-containing structures bearing contiguous stereocenters, which have great relevance in natural product synthesis, drug development and the design and synthesis of chiral catalysts/ligands for asymmetric catalysis. This review outlines the advances achieved in the catalytic asymmetric desymmetrization of aziridines and highlights some promising avenues for further work in this realm.
作为一类易于获得的小张力环杂环化合物，氮丙啶可进行催化去对称化转化，以快速构建具有相邻立体中心的多种含氮结构，这在天然产物合成、药物开发以及不对称催化的手性催化剂/配体的设计与合成中具有重要意义。本综述概述了氮丙啶催化不对称去对称化所取得的进展，并突出了该领域进一步研究的一些有前景的方向。
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