Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Medical Physics Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.
PLoS One. 2022 Dec 12;17(12):e0278966. doi: 10.1371/journal.pone.0278966. eCollection 2022.
Microtubule-associated 1B (MAP1B) proteins are expressed at the nervous system level where they control cytoskeleton activity and regulate neurotransmitter release. Here, we report about the identification of a planarian MAP1B factor (DjMap1B) that is enriched in cephalic ganglia and longitudinal nerve cords but not in neoblasts, the plentiful population of adult stem cells present in planarians, thanks to which these animals can continuously cell turnover and regenerate any lost body parts. DjMap1B knockdown induces morphological anomalies in the nervous system and affects neoblast commitment. Our data put forward a correlation between a MAP1B factor and stem cells and suggest a function of the nervous system in non-cell autonomous control of planarian stem cells.
微管相关蛋白 1B（MAP1B）在神经系统中表达，它们控制细胞骨架的活性并调节神经递质的释放。在这里，我们报告了一种涡虫 MAP1B 因子（DjMap1B）的鉴定，该因子在头神经节和纵神经索中富集，但不在涡虫的成体干细胞（neoblast）中富集，neoblast 是涡虫中大量存在的成体干细胞，这些细胞使涡虫能够持续细胞更新并再生任何丢失的身体部位。DjMap1B 的敲低会诱导神经系统的形态异常，并影响成体干细胞的定向分化。我们的数据表明，MAP1B 因子与成体干细胞之间存在相关性，并提示神经系统在非细胞自主控制涡虫成体干细胞方面的功能。
