庆大霉素与甲氧苄啶或磺胺甲恶唑-甲氧苄啶联合对大肠杆菌和肺炎克雷伯菌的协同活性。
Synergistic activity of gentamicin with trimethoprim or sulfamethoxazole-trimethoprim against Escherichia coli and Klebsiella pneumoniae.
作者信息
Paisley J W, Washington J A
出版信息
Antimicrob Agents Chemother. 1978 Nov;14(5):656-8. doi: 10.1128/AAC.14.5.656.
The effect of combinations of gentamicin with trimethoprim or sulfamethoxazole-trimethoprim against clinical isolates of Escherichia coli (11 strains) and Klebsiella pneumoniae (12 strains) was examined by using a microdilution checkerboard technique. All isolates were susceptible to each antimicrobial agent. Synergism, defined as at least a 2-log(2)-dilution lowering of the minimal inhibitory concentration of either antibiotic in the combination compared with the minimal inhibitory concentration of the antibiotic alone, was observed with 15 of 23 (65%) isolates tested against trimethoprim and gentamicin and 14 of 23 (61%) isolates tested against sulfamethoxazole-trimethoprim and gentamicin. A 3-log(2)-dilution lowering of the minimal inhibitory concentration of either antibiotic was observed in 7 of 23 (30%) trimethoprim and gentamicin trials and 3 of 23 (13%) sulfamethoxazole-trimethoprim and gentamicin trials. Antagonism was observed in 3 of 46 combination trials and only with strains of K. pneumoniae.
采用微量稀释棋盘法检测了庆大霉素与甲氧苄啶或磺胺甲恶唑 - 甲氧苄啶联合使用对大肠杆菌临床分离株（11株）和肺炎克雷伯菌临床分离株（12株）的效果。所有分离株对每种抗菌药物均敏感。与单独使用抗生素的最低抑菌浓度相比，联合使用时两种抗生素中任一抗生素的最低抑菌浓度至少降低2个对数（2）倍稀释度被定义为协同作用，在测试的23株分离株中，15株（65%）对甲氧苄啶和庆大霉素的联合表现出协同作用，14株（61%）对磺胺甲恶唑 - 甲氧苄啶和庆大霉素的联合表现出协同作用。在23次甲氧苄啶和庆大霉素联合试验中的7次（30%）以及23次磺胺甲恶唑 - 甲氧苄啶和庆大霉素联合试验中的3次（13%）观察到两种抗生素中任一抗生素的最低抑菌浓度降低3个对数（2）倍稀释度。在46次联合试验中的3次观察到拮抗作用，且仅在肺炎克雷伯菌菌株中出现。
Zotero 插件