革兰氏阴性菌感染中抗生素体外协同作用的临床意义。
Clinical significance of in vitro synergism between antibiotics in gram-negative infections.
作者信息
Klastersky J, Cappel R, Daneau D
出版信息
Antimicrob Agents Chemother. 1972 Dec;2(6):470-5. doi: 10.1128/AAC.2.6.470.
Abstract
Five combinations of antibiotics (ampicillin/gentamicin, cephalothin/gentamicin, carbenicillin/gentamicin, polymyxin/carbenicillin, and carbenicillin/cephalothin) were investigated in vitro and in 148 severe infectious episodes caused by gram-negative bacilli in patients with disseminated cancer. The use of combinations that were synergistic in vitro against the offending microorganism (synergy was defined as occurring when the minimal inhibitory concentration of each of the drugs in the combination was one-quarter or less of the minimal inhibitory concentration of each drug alone) was associated with a significantly better response to antibacterial therapy (P < 0.01) than the use of combinations that were not synergistic against the causative agent.
摘要
对五种抗生素组合（氨苄西林/庆大霉素、头孢噻吩/庆大霉素、羧苄西林/庆大霉素、多粘菌素/羧苄西林以及羧苄西林/头孢噻吩）进行了体外研究，并在148例播散性癌症患者由革兰氏阴性杆菌引起的严重感染发作中进行了研究。对于体外对致病微生物具有协同作用的组合（协同作用定义为当组合中每种药物的最低抑菌浓度是每种药物单独使用时最低抑菌浓度的四分之一或更低时发生），与对致病因子无协同作用的组合相比，其抗菌治疗反应明显更好（P < 0.01）。
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