猴痘感染致角膜溃疡。
Corneal Ulcer due to Monkeypox Infection.
机构信息
Ophthalmology, University Hospital of Santiago de Compostela, Santiago, Spain.
Microbiology, University Hospital of Santiago de Compostela, Santiago, Spain.
出版信息
Ocul Immunol Inflamm. 2024 Apr;32(3):259-261. doi: 10.1080/09273948.2022.2153343. Epub 2022 Dec 12.
PURPOSE
To report a rare case of keratitis due to monkeypox infection.
METHODS
A 45-year-old male presented with an epithelial corneal ulcer 20 days following initial diagnosis of monkeypox from genital and perioral lesions. PCR analysis of the epithelium confirmed the presence of human monkeypox virus.
RESULTS
The patient was hospitalized, and ganciclovir gel, as well as povidone iodine 0.6% and moxifloxacin eyedrops were prescribed. Oral tecovirimat 600 mg was administered during 14 days. A therapeutic contact lens was used. Twenty days after the initial diagnosis of keratitis, the corneal defect closed leaving a faint subepithelial haze, and visual acuity was 0.8.
CONCLUSIONS
This is an uncommon case report of epithelial keratitis due to human monkeypox. PCR positivity for monkeypox in the corneal epithelium confirmed the presence of viral material in the cornea.
目的
报告一例罕见的猴痘感染性角膜炎病例。
方法
一名 45 岁男性，最初诊断为生殖器和口周病变的猴痘后 20 天出现上皮性角膜溃疡。对上皮组织进行 PCR 分析证实存在人类猴痘病毒。
结果
患者住院，给予更昔洛韦凝胶以及聚维酮碘 0.6%和莫西沙星滴眼液治疗。口服特考韦瑞 600mg，治疗 14 天。使用治疗性隐形眼镜。初次诊断角膜炎后 20 天，角膜缺损闭合，仅留下轻微的上皮下混浊，视力为 0.8。
结论
这是一例罕见的人类猴痘引起的上皮性角膜炎病例报告。角膜上皮的猴痘 PCR 阳性证实了病毒物质存在于角膜中。
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