Rojas-Carabali William, Cifuentes-González Carlos, Agrawal Rupesh, de-la-Torre Alejandra
Neuroscience (NEUROS) Research Group, Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Colombia.
Advanced Ophthalmic Imaging Laboratory, Department of Ophthalmology, New York University School of Medicine, USA.
Heliyon. 2023 Jul 22;9(8):e18561. doi: 10.1016/j.heliyon.2023.e18561. eCollection 2023 Aug.
Mpox virus infection is a significant public health concern worldwide due to its potential severity and the likelihood of outbreaks occurring across different regions. Ophthalmic manifestations of the disease have been linked with more severe cases, leading to the need for hospitalization and antiviral therapy. A systematic review and meta-analysis were conducted following PRISMA guidelines to summarize the literature available on this topic. The review revealed that ophthalmic manifestations, such as conjunctivitis and periocular umbilicated lesions, are the most common in Mpox virus infections. However, severe manifestations, such as corneal opacity, that can potentially cause blindness may also occur. Antiviral treatment with tecovirimat and topical management for conjunctivitis can be considered for severe cases. However, the evidence quality is poor due to the predominance of case reports and imprecise characterization of the ophthalmic manifestations. Overall, ophthalmologists and healthcare professionals should be aware of these manifestations for early diagnosis and timely treatment.
由于猴痘病毒感染的潜在严重性以及在不同地区爆发的可能性，它已成为全球重大的公共卫生问题。该疾病的眼部表现与更严重的病例相关，这导致需要住院治疗和抗病毒治疗。按照PRISMA指南进行了一项系统评价和荟萃分析，以总结关于该主题的现有文献。该评价显示，眼部表现，如结膜炎和眼周脐状病变，在猴痘病毒感染中最为常见。然而，也可能出现严重表现，如可能导致失明的角膜混浊。对于严重病例，可考虑使用特考韦瑞进行抗病毒治疗以及对结膜炎进行局部处理。然而，由于病例报告占主导且眼部表现的特征描述不精确，证据质量较差。总体而言，眼科医生和医护人员应了解这些表现以便早期诊断和及时治疗。
