Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Dr. Nasser Al-Rashid Research Chair in Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Ocul Immunol Inflamm. 2024 Aug;32(6):912-918. doi: 10.1080/09273948.2022.2150226. Epub 2022 Dec 12.
To evaluate risk factors for developing endophthalmitis after repair of open globe injuries.
Retrospective chart analysis of 1303 patients from May 1996 till December 2019.
All patients received prophylactic intravenous broad-spectrum antibiotics for 5-7 days. Endophthalmitis was clinically suspected in 37 (2.8%) eyes and was culture proven in 14 of these eyes (1.1%). Univariate analysis identified poor initial visual acuity at presentation, rural setting of injury, contaminated wound and lens injury as significant predictors for the development of clinically suspected endophthalmitis. Intravitreal antibiotics at the time of primary repair in eyes with high-risk characteristics decreased risk of developing endophthalmitis (OR: 2.28;95% CI,1.07-4.86; = .033).
Poor initial visual acuity, rural setting of injury, contaminated wound, and lens injury increased risk of suspected posttraumatic endophthalmitis. Prophylactic intravitreal antibiotics at the time of primary repair in eyes with high-risk characteristics reduced the risk of posttraumatic endophthalmitis.
评估开放性眼球损伤修复后发生眼内炎的危险因素。
对 1996 年 5 月至 2019 年 12 月的 1303 例患者进行回顾性图表分析。
所有患者均接受 5-7 天预防性静脉注射广谱抗生素。37 只（2.8%）眼临床怀疑眼内炎，并在其中 14 只眼（1.1%）培养证实。单因素分析发现，就诊时初始视力差、损伤发生在农村地区、污染伤口和晶状体损伤是发生临床疑似眼内炎的显著预测因素。在具有高危特征的眼行初次修复时，玻璃体内给予抗生素可降低发生眼内炎的风险（OR：2.28；95%CI，1.07-4.86； =.033）。
初始视力差、损伤发生在农村地区、污染伤口和晶状体损伤增加了疑似创伤性眼内炎的风险。在具有高危特征的眼行初次修复时预防性玻璃体内给予抗生素可降低创伤性眼内炎的风险。
