食用桑椹对心血管代谢危险因素的影响：随机对照试验的系统评价和荟萃分析
Impact of mulberry consumption on cardiometabolic risk factors: A systematic review and meta-analysis of randomized-controlled trials.
作者信息
Chen Xibin, Sohouli Mohammad Hassan, Nateghi Mahsa, Melekoglu Ebru, Fatahi Somaye
机构信息
Department of Catheter, The First People's Hospital of Lianyungang, Lianyungang, China.
Student Research Committee, Department of Clinical Nutrition and Dietetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
J Clin Pharm Ther. 2022 Dec;47(12):1982-1993. doi: 10.1111/jcpt.13822. Epub 2022 Dec 12.
OBJECTIVE
The current study aimed to comprehensively evaluate the potential effects of mulberry consumption on cardiometabolic risk factors in adults.
METHODS
Relevant articles published up to January 2021 were systematically retrieved from SCOPUS, PubMed/MEDLINE, EMBASE, and Web of Science databases. We included all randomized controlled trials (RCTs) investigating the impact of mulberry consumption on various cardiometabolic risk factors.
RESULTS
The quantitative meta-analysis of 12 eligible RCTs demonstrated a significant reducing effect of mulberry consumption on haemoglobin A1c (HbA1c) (weighted mean difference [WMD]: -0. 55, 95% CI: -1.08, -0.02, p = 0.044), serum total cholesterol (TC) (WMD: -13.13 mg/dl, 95% CI: -19.06, -7.20, p < 0.001), low-density lipoprotein levels (LDL-C) (WMD: -8.84 mg/dl, 95% CI: -13.26, -4.42, p < 0.001), triglycerides (TG) (WMD: -19.67 mg/dl, 95% CI: -30.13, -9.22, p < 0.001) and C-reactive protein (CRP) (WMD: -1.60, mg/L, 95% CI: -3.07, -0.12, p = 0.034). Also, >300 mg daily intake of mulberry exhibited a favourable effect on serum high-density lipoprotein levels (HDL-C). However, there were no significant differences between mulberry intervention and control groups for other factors.
CONCLUSION
The current systematic review and meta-analysis revealed that incorporating mulberry into the diet may favourably affect several cardiometabolic risk factors.
目的
本研究旨在全面评估食用桑椹对成年人心脏代谢危险因素的潜在影响。
方法
截至2021年1月发表的相关文章从SCOPUS、PubMed/MEDLINE、EMBASE和Web of Science数据库中系统检索。我们纳入了所有研究食用桑椹对各种心脏代谢危险因素影响的随机对照试验（RCT）。
结果
对12项符合条件的随机对照试验进行的定量荟萃分析表明，食用桑椹对糖化血红蛋白（HbA1c）有显著降低作用（加权平均差[WMD]：-0.55，95%置信区间：-1.08，-0.02，p = 0.044），血清总胆固醇（TC）（WMD：-13.13mg/dl，95%置信区间：-19.06，-7.20，p < 0.001），低密度脂蛋白水平（LDL-C）（WMD：-8.84mg/dl，95%置信区间：-13.26，-4.42，p < 0.001），甘油三酯（TG）（WMD：-19.67mg/dl，95%置信区间：-30.13，-9.22，p < 0.001）和C反应蛋白（CRP）（WMD：-1.60mg/L，95%置信区间：-3.07，-0.12，p = 0.034）。此外，每日摄入>300mg桑椹对血清高密度脂蛋白水平（HDL-C）有有利影响。然而，在其他因素方面，桑椹干预组和对照组之间没有显著差异。
结论
当前的系统评价和荟萃分析表明，将桑椹纳入饮食可能对几种心脏代谢危险因素产生有利影响。
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