Hariri Mitra, Amirkalali Bahareh, Mollanoroozy Ensiyeh, Gholami Ali
Noncommunicable Diseases Research Center Neyshabur University of Medical Sciences Neyshabur Iran.
Gastrointestinal & Liver Diseases Research Center Iran University of Medical Sciences Tehran Iran.
Food Sci Nutr. 2022 Sep 15;10(12):4126-4138. doi: 10.1002/fsn3.3038. eCollection 2022 Dec.
Some studies proposed the anti-inflammatory effect of soy protein and soy isoflavones by changing the serum adiponectin and resistin levels. The purpose of this research was to determine the impact of soy isoflavones and soy protein on blood adiponectin and resistin levels in adults. Scopus, PubMed, Cochrane Library, ISI Web of Science, and ClinicalTrials.gov databases were searched until April 2022. The effect size was computed by the mean changes from the beginning for intervention and comparison groups and their standard deviation. In the case of significant heterogeneity, DerSimonian and Laird random-effects model was used. Six and five clinical trials were selected for the systematic review and meta-analysis, respectively. The overall estimate indicated that soy isoflavones in combination with soy protein did not significantly change serum adiponectin level (weighted mean differences (WMD) = 0.36 μg/ml; 95% confidence interval (CI): -0.26, 0.99; = .25), but significantly increased serum resistin level (WMD = 0.64 ng/ml, 95% CI: 0.25, 1.04; = .001). In combination with soy protein, soy isoflavones nonsignificantly increased serum adiponectin levels, but significantly increased resistin levels. New intervention studies with a high dose of soy isoflavones and soy protein in different parts of the world and an updated meta-analysis are needed to confirm the results of our study.
一些研究提出，大豆蛋白和大豆异黄酮可通过改变血清脂联素和抵抗素水平发挥抗炎作用。本研究的目的是确定大豆异黄酮和大豆蛋白对成年人血液中脂联素和抵抗素水平的影响。检索了Scopus、PubMed、Cochrane图书馆、ISI科学网和ClinicalTrials.gov数据库，检索截至2022年4月。效应量通过干预组和对照组从开始时的平均变化及其标准差计算得出。在存在显著异质性的情况下，使用DerSimonian和Laird随机效应模型。分别选择了6项和5项临床试验进行系统评价和荟萃分析。总体估计表明，大豆异黄酮与大豆蛋白联合使用不会显著改变血清脂联素水平（加权平均差（WMD）=0.36μg/ml；95%置信区间（CI）：-0.26，0.99；P=0.25），但会显著提高血清抵抗素水平（WMD=0.64ng/ml，95%CI：0.25，1.04；P=0.001）。与大豆蛋白联合使用时，大豆异黄酮不会显著提高血清脂联素水平，但会显著提高抵抗素水平。需要在世界不同地区进行高剂量大豆异黄酮和大豆蛋白的新干预研究以及更新的荟萃分析来证实我们的研究结果。
