Rheumatology Department Reina Sofia University Hospital, Córdoba, Spain; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain.
Rheumatology Department Reina Sofia University Hospital, Córdoba, Spain; Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain; University of Córdoba, Córdoba, Spain.
Semin Arthritis Rheum. 2023 Feb;58:152146. doi: 10.1016/j.semarthrit.2022.152146. Epub 2022 Nov 30.
An inverse association between alcohol consumption and disease activity and functional impairment has been observed in patients with spondyloarthritis (SpA). However, neither this association nor the influence of smoking has been investigated in peripheral manifestations of SpA.
The objective of this study was to analyze the association between smoking and alcohol consumption and the presence of peripheral musculoskeletal manifestations (arthritis, enthesitis or dactylitis) and to determine the specific location of these manifestations.
Patients from the worldwide cross-sectional ASAS-PerSpA study with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or psoriatic arthritis (PsA) according to their rheumatologist were included. Generalised linear mixed models used peripheral manifestation (or location) as a dependent variable, smoking status and alcohol consumption as fixed effects and country as a random effect. The interaction between smoking and alcohol was tested. Analyses were performed for each diagnosis (axSpA, pSpA and PsA).
A total of 4181 patients were included. In axSpA patients, smoking was associated with a lower prevalence of any peripheral manifestation, and current alcohol consumption was associated with a lower prevalence of both current arthritis and current enthesitis. In pSpA patients, current alcohol consumption was associated with a lower prevalence of current arthritis or enthesitis. In PsA patients, a significant association was found for arthritis with smoking and for enthesitis with alcohol consumption, and current alcohol consumption was associated with a lower prevalence of current arthritis or enthesitis.
Taking into account the country, smoking and alcohol are associated with a lower prevalence of peripheral manifestations.
在患有脊柱关节炎 (SpA) 的患者中，观察到饮酒与疾病活动和功能障碍呈负相关。然而，在 SpA 的外周表现中，尚未研究这种关联或吸烟的影响。
本研究的目的是分析吸烟和饮酒与外周肌肉骨骼表现（关节炎、肌腱炎或指炎）的存在之间的关联，并确定这些表现的具体位置。
纳入了根据风湿病医生诊断为中轴型 SpA（axSpA）、外周型 SpA（pSpA）或银屑病关节炎（PsA）的来自 ASAS-PerSpA 研究的全球横断面研究的患者。使用广义线性混合模型将外周表现（或位置）作为因变量，吸烟状况和饮酒作为固定效应，国家作为随机效应。测试了吸烟和饮酒之间的相互作用。对每种诊断（axSpA、pSpA 和 PsA）进行了分析。
共纳入 4181 例患者。在 axSpA 患者中，吸烟与任何外周表现的患病率较低相关，而当前饮酒与当前关节炎和当前肌腱炎的患病率较低相关。在 pSpA 患者中，当前饮酒与当前关节炎或肌腱炎的患病率较低相关。在 PsA 患者中，发现吸烟与关节炎之间存在显著关联，饮酒与肌腱炎之间存在关联，当前饮酒与当前关节炎或肌腱炎的患病率较低相关。
考虑到国家因素，吸烟和饮酒与外周表现的患病率较低有关。
