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移民非小细胞肺癌患者的护理模式和结局。一项基于人群的研究(瑞典)。

Patterns of care and outcomes in immigrants with non-small cell lung cancer. A population-based study (Sweden).

机构信息

Center for Research and Development, Uppsala University/Region Gävleborg, Gävle, Sweden.

Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.

出版信息

PLoS One. 2022 Dec 15;17(12):e0278706. doi: 10.1371/journal.pone.0278706. eCollection 2022.


DOI:10.1371/journal.pone.0278706
PMID:36520832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9754210/
Abstract

OBJECTIVES: While studies have found lower cancer risks and better cancer survival in immigrant populations, it is debated whether cancer care is offered on equal terms to all residents regardless of background. Our aim was to study patterns of care and outcomes in immigrants in a country with a tax-financed universal health care system. MATERIAL AND METHODS: We used a population-based database to compare clinical presentation, management and mortality between Swedish-born and immigrant patients with non-small cell lung cancer (NSCLC). Analyses were adjusted for potential confounders. RESULTS: We identified 40,075 patients diagnosed with NSCLC of which 84% were born in Sweden, 7% in Nordic and 9% in Non-Nordic countries. Non-Nordic immigrants were to a higher extent male, smokers, younger at diagnosis, had a better performance status and a higher educational level. No differences were seen regarding comorbidity burden or stage at diagnosis. Non-Nordic immigrants more often underwent positron emission tomography (PET) (aHR 1.32; 95% CI 1.19-1.45) and were more often discussed in a multidisciplinary team setting (aHR 1.30; 95% CI 1.17-1.44). There were no differences in treatment modalities following adjustment for age, with the exception of concurrent chemoradiotherapy in stage IIIA disease which was more common in Non-Nordic immigrants (aOR 1.34; 95% CI 1.03-1.74). Both overall and cause specific survival in non-metastatic disease were higher among Non-Nordic immigrants. Overall mortality in stage I-II: HR 0.81; 95% CI 0.73-0.90 and stage IIIA: HR 0.75; 95% CI 0.65-0.86. Following full adjustments, cause-specific mortality in stage I-II was aHR 0.86, 95% CI 0.75-0.98. CONCLUSION: Taken together, only minor differences in management and outcomes were observed between Swedish-born and immigrant patients. We conclude that lung cancer care is offered on equal terms. If anything, outcomes were better in Non-Nordic immigrants with early stage NSCLC.

摘要

目的:虽然研究发现移民人群的癌症风险较低且癌症存活率更高,但仍存在争议,即无论背景如何,所有居民是否都能获得同等的癌症治疗。我们的目的是研究在一个拥有税收资助的全民医疗保健系统的国家中,移民的治疗模式和结局。

材料和方法:我们使用基于人群的数据库比较了瑞典出生和移民的非小细胞肺癌(NSCLC)患者的临床表现、治疗和死亡率。分析中调整了潜在混杂因素。

结果:我们确定了 40075 例 NSCLC 患者,其中 84%出生于瑞典,7%出生于北欧国家,9%出生于非北欧国家。非北欧移民更多为男性、吸烟者、诊断时年龄较小、表现状态更好、教育程度更高。在合并症负担或诊断时的分期方面没有差异。非北欧移民更常接受正电子发射断层扫描(PET)(aHR 1.32;95%CI 1.19-1.45),并且更常在多学科团队环境中进行讨论(aHR 1.30;95%CI 1.17-1.44)。在调整年龄后,治疗方式没有差异,除了 IIIA 期疾病的同步放化疗更为常见(aOR 1.34;95%CI 1.03-1.74)。非转移性疾病的总生存率和特定病因生存率在非北欧移民中均较高。I-II 期的总死亡率:HR 0.81;95%CI 0.73-0.90 和 IIIA 期:HR 0.75;95%CI 0.65-0.86。经过全面调整,I-II 期的特定病因死亡率为 aHR 0.86,95%CI 0.75-0.98。

结论:总体而言,瑞典出生和移民患者的治疗和结局仅存在细微差异。我们得出的结论是,肺癌治疗是平等提供的。如果有的话,非北欧移民的早期 NSCLC 结局更好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a10c/9754210/44c7db9a9395/pone.0278706.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a10c/9754210/44c7db9a9395/pone.0278706.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a10c/9754210/44c7db9a9395/pone.0278706.g001.jpg

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引用本文的文献

[1]
Disparities in overall and site-specific cancer mortality among immigrant generations in Sweden: a nationwide follow-up study over 3 decades.

Am J Epidemiol. 2025-8-5

[2]
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Clin Transl Radiat Oncol. 2023-12-18

本文引用的文献

[1]
Home and away: mortality among Finnish-born migrants in Sweden compared to native Swedes and Finns residing in Finland.

Eur J Public Health. 2021-4-24

[2]
Cancer incidence in non-immigrants and immigrants in Norway.

Acta Oncol. 2020-11

[3]
Genomic landscape of lung adenocarcinoma in East Asians.

Nat Genet. 2020-2-3

[4]
Sex and survival in non-small cell lung cancer: A nationwide cohort study.

PLoS One. 2019-6-27

[5]
Educational level and management and outcomes in non-small cell lung cancer. A nationwide population-based study.

Lung Cancer. 2019-3-7

[6]
Differences in cancer survival between immigrants in Norway and the host population.

Int J Cancer. 2018-12-15

[7]
Patterns of treatment and survival among older patients with stage III non-small cell lung cancer.

Lung Cancer. 2017-12-20

[8]
The Swedish cause of death register.

Eur J Epidemiol. 2017-9

[9]
Impact of Immigration Status on Cancer Outcomes in Ontario, Canada.

J Oncol Pract. 2017-7

[10]
Mortality by country of birth in the Nordic countries - a systematic review of the literature.

BMC Public Health. 2017-5-25

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