Hawthorn J, Nussey S S, Henderson J R, Jenkins J S
Department of Medicine II, St. George's Hospital Medical School, London, United Kingdom.
Cell Tissue Res. 1987 Oct;250(1):1-6. doi: 10.1007/BF00214646.
The distribution of oxytocin and vasopressin in the adrenals of rat, cow, hamster and guinea pig has been studied by use of immunohistochemical techniques. In all the species studied the adrenal cortex contained both peptides; the staining in the zona glomerulosa being more intense than that in zona fasciculata or zona reticularis. The medulla, however, showed considerable species variation. In the cow, both peptides appear to be present in the adrenergic and noradrenergic cells, though staining was particularly prominent in cortical islands interspersed within the medullary tissue. In the rat, groups of medullary cells positive for both peptides were found, though it was not possible to associate these groups with particular chromaffin cell types. In the hamster oxytocin was present only in adrenaline-containing cells, whereas vasopressin was present in all medullary cells. The guinea pig medulla, which contains only adrenaline-secreting cells, was positive for both peptides. The possibilities that vasopressin and oxytocin have an autocrine or paracrine role in functioning of the adrenal gland is discussed.
利用免疫组织化学技术研究了大鼠、牛、仓鼠和豚鼠肾上腺中催产素和加压素的分布情况。在所研究的所有物种中，肾上腺皮质均含有这两种肽；球状带的染色比束状带或网状带更强烈。然而，髓质表现出相当大的物种差异。在牛中，这两种肽似乎都存在于肾上腺素能和去甲肾上腺素能细胞中，尽管在散布于髓质组织内的皮质岛中染色尤为明显。在大鼠中，发现了两组对这两种肽均呈阳性的髓质细胞，尽管无法将这些组与特定的嗜铬细胞类型联系起来。在仓鼠中，催产素仅存在于含肾上腺素的细胞中，而加压素存在于所有髓质细胞中。豚鼠的髓质仅含分泌肾上腺素的细胞，对这两种肽均呈阳性。文中讨论了加压素和催产素在肾上腺功能中具有自分泌或旁分泌作用的可能性。
