原子力显微镜红外光谱在药物递送载体表征中的应用：纳米尺度下的红外、热和机械表征。

Applications of AFM-IR for drug delivery vector characterization: infrared, thermal, and mechanical characterization at the nanoscale.

作者信息

Zhang Jing, Khanal Dipesh, Banaszak Holl Mark M

机构信息

Department of Chemical & Biological Engineering, Monash University, Clayton, Victoria 3800, Australia.

Advanced Drug Delivery Group, School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, NSW 2006, Australia; The University of Sydney, Sydney Nano Institute, Sydney, New South Wales 2006, Australia.

出版信息

Adv Drug Deliv Rev. 2023 Jan;192:114646. doi: 10.1016/j.addr.2022.114646. Epub 2022 Dec 13.

DOI:10.1016/j.addr.2022.114646

PMID:36521685

Abstract

The development of effective drug delivery systems requires in-depth characterization of the micro- or nanostructure of the material vectors with high spatial resolution, resulting in a deep understanding of the design-function relationship and maximum therapeutic efficacy. Atomic force microscopy-infrared spectroscopy (AFM-IR) combines the high spatial resolution of AFM and the capabilities of IR spectroscopy to identify chemical composition and it has emerged as a powerful tool for the detailed characterization of a drug delivery system at the nanoscale. In addition, the instruments also allow thermal and mechanical evaluation at the nanoscale. In this review, we highlight the applications of AFM-IR in various drug delivery systems, including polymer-based carriers, lipid-contained nanocarriers, and metal-based nanocarriers. The existing challenges as well as the future perspectives for the application of AFM-IR for drug delivery vector characterization are also discussed.

摘要

有效的药物递送系统的开发需要以高空间分辨率对材料载体的微观或纳米结构进行深入表征，从而深入理解设计-功能关系并实现最大治疗效果。原子力显微镜-红外光谱（AFM-IR）结合了AFM的高空间分辨率和红外光谱识别化学成分的能力，已成为在纳米尺度上详细表征药物递送系统的强大工具。此外，这些仪器还允许在纳米尺度上进行热学和力学评估。在本综述中，我们重点介绍了AFM-IR在各种药物递送系统中的应用，包括聚合物基载体、含脂质纳米载体和金属基纳米载体。还讨论了AFM-IR用于药物递送载体表征的现有挑战以及未来前景。