Faculty of Chemical Engineering, University of Campinas (UNICAMP), Campinas, Brazil.
Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, Brazil.
J Control Release. 2023 Jan;353:802-822. doi: 10.1016/j.jconrel.2022.12.017. Epub 2022 Dec 17.
This paper provides a review of the literature on the use of Pluronic® triblock copolymers for drug encapsulation over the last 10 years. A special focus is given to the progress of drug delivery systems (e.g., micelles, liposomes, micro/nanoemulsions, hydrogels and nanogels, and polymersomes and niosomes); the beneficial aspects of Pluronic® triblock copolymers as biological response modifiers and as pharmaceutical additives, adjuvants, and stabilizers, are also discussed. The advantages and limitations encountered in developing site-specific targeting approaches based on Pluronic-based nanostructures in cancer treatment are highlighted, in addition to innovative examples for improving tumor cytotoxicity while reducing side effects.
本文综述了过去 10 年中 Pluronic®嵌段共聚物在药物包封方面的文献。特别关注药物传递系统的进展（例如胶束、脂质体、微/纳米乳液、水凝胶和纳米凝胶以及聚合物囊泡和非离子囊泡）；还讨论了 Pluronic®嵌段共聚物作为生物反应调节剂以及作为药物添加剂、佐剂和稳定剂的有益方面。本文还强调了基于基于 Pluronic 的纳米结构在癌症治疗中开发定位靶向方法所遇到的优势和局限性，以及在提高肿瘤细胞毒性同时降低副作用方面的创新实例。
