Department of Pharmacology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
Department of Pharmacology, Moores Cancer Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA; Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA.
Semin Cancer Biol. 2023 Jan;88:46-66. doi: 10.1016/j.semcancer.2022.12.002. Epub 2022 Dec 13.
Epithelial-mesenchymal transition (EMT) has been implicated in various aspects of tumor development, including tumor invasion and metastasis, cancer stemness, and therapy resistance. Diverse stroma cell types along with biochemical and biophysical factors in the tumor microenvironment impinge on the EMT program to impact tumor progression. Here we provide an in-depth review of various tumor microenvironmental signals that regulate EMT in cancer. We discuss the molecular mechanisms underlying the role of EMT in therapy resistance and highlight new therapeutic approaches targeting the tumor microenvironment to impact EMT and tumor progression.
上皮-间充质转化 (EMT) 涉及肿瘤发生的多个方面，包括肿瘤侵袭和转移、癌症干细胞特性和治疗耐药性。肿瘤微环境中的多种基质细胞类型以及生化和生物物理因素影响 EMT 程序，从而影响肿瘤进展。在这里，我们深入回顾了各种调节肿瘤中 EMT 的肿瘤微环境信号。我们讨论了 EMT 在治疗耐药性中作用的分子机制，并强调了针对肿瘤微环境的新治疗方法，以影响 EMT 和肿瘤进展。
Zotero 插件
