Sjaastad O, Antonaci F
Department of Neurology, Regionsykehuset, Trondheim University Hospital, Norway.
Cephalalgia. 1987 Sep;7(3):203-5. doi: 10.1046/j.1468-2982.1987.0703203.x.
In a 38-year-old woman who had had CPH since the middle 1960s and had been successfully treated with indomethacin (dosage usually within the limits of 50-175 mg/day) for approximately 10 years, the requirement for indomethacin was gradually reduced to nought in the spring of 1985. She was then pain-free without indomethacin for almost 1 1/2 years. In the late fall of 1986 she had a 3-week exacerbation. In recent months, she again seems to have a slowly increasing, although clearly fluctuating, indomethacin requirement. Long-lasting remissions may thus appear even in the chronic stage. The remission could be a spontaneous one or it could in some way be related to the protracted indomethacin treatment; the authors favour the former possibility. The recurrence of symptoms after a while shows that the attack-generating potential has not been permanently extinguished by indomethacin.
一名38岁女性自20世纪60年代中期起患有慢性复发性多软骨炎（CPH），并成功使用吲哚美辛（剂量通常在50 - 175毫克/天范围内）治疗了约10年。1985年春季，她对吲哚美辛的需求逐渐降至零。此后，在未使用吲哚美辛的情况下，她几乎1年半都没有疼痛。1986年秋末，病情加重了3周。近几个月来，她似乎再次出现对吲哚美辛的需求缓慢增加，尽管明显波动。因此，即使在慢性阶段也可能出现持久缓解。缓解可能是自发的，也可能在某种程度上与长期使用吲哚美辛治疗有关；作者倾向于前一种可能性。一段时间后症状复发表明，吲哚美辛并未永久消除引发发作的可能性。
