Chen Chongyang, Liu Jingfang
The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Department of Endocrinology, the First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Front Oncol. 2022 Nov 29;12:1053618. doi: 10.3389/fonc.2022.1053618. eCollection 2022.
Thyroid cancer is a common malignancy of the endocrine system, with papillary thyroid cancer (PTC) being the most common type of pathology. The incidence of PTC is increasing every year. Histone acetylation modification is an important part of epigenetics, regulating histone acetylation levels through histone acetylases and histone deacetylases, which alters the proliferation and differentiation of PTC cells and affects the treatment and prognosis of PTC patients. Histone deacetylase inhibitors induce histone acetylation, resulting in the relaxation of chromatin structure and activation of gene transcription, thereby promoting differentiation, apoptosis, and growth arrest of PTC cells.
甲状腺癌是内分泌系统常见的恶性肿瘤，其中甲状腺乳头状癌（PTC）是最常见的病理类型。PTC的发病率逐年上升。组蛋白乙酰化修饰是表观遗传学的重要组成部分，通过组蛋白乙酰转移酶和组蛋白去乙酰化酶调节组蛋白乙酰化水平，这会改变PTC细胞的增殖和分化，并影响PTC患者的治疗和预后。组蛋白去乙酰化酶抑制剂可诱导组蛋白乙酰化，导致染色质结构松弛和基因转录激活，从而促进PTC细胞的分化、凋亡和生长停滞。
