Department of Food Science and Engineering, Jinan University, Guangzhou, 510632 Guangdong, China.
J Agric Food Chem. 2023 Jan 11;71(1):320-330. doi: 10.1021/acs.jafc.2c04017. Epub 2022 Dec 18.
The metabolic disease hyperuricemia (HUA) is characterized by a disturbance in purine metabolism. Peptides, such as marine fish-derived peptides, have previously been shown to be effective in alleviating HUA. In this study, HUA rats were induced by potassium oxonate with 100 mg/kg (L), 200 mg/kg (M), and 400 mg/kg (H) of marine fish protein peptide (MFPP). The results showed that MFPP could effectively reduce the serum uric acid (SUA) levels compared with the model group rats; kidney histopathology and the levels of inflammatory factors (TNF-α, IL-6, and IL-10) indicated that MFPP attenuated HUA-induced kidney inflammation. Meanwhile, MFPP restored the abundance of beneficial bacteria, including , , , and . MFPP further repaired the intestinal barrier by recovering the expression of gene encoding the tricellular tight junction protein ILDR2 and the immune-related genes and and also regulated the expression of and to restore kidney function and uric acid metabolism. MFPP was proved to have potential as a therapeutic strategy to be included in dietary intervention to relieve HUA.
代谢性疾病高尿酸血症（HUA）的特征是嘌呤代谢紊乱。肽类物质，如海洋鱼类来源的肽类，已被证明在缓解 HUA 方面具有有效性。在这项研究中，通过给予氧嗪酸钾诱导 HUA 大鼠，剂量分别为 100mg/kg（L）、200mg/kg（M）和 400mg/kg（H）的海洋鱼蛋白肽（MFPP）。结果表明，与模型组大鼠相比，MFPP 能有效降低血清尿酸（SUA）水平；肾脏组织病理学和炎症因子（TNF-α、IL-6 和 IL-10）水平表明，MFPP 减轻了 HUA 引起的肾脏炎症。同时，MFPP 通过恢复编码三细胞紧密连接蛋白 ILDR2 的基因的表达以及免疫相关基因 和 ，并调节 和 的表达，恢复了肠道屏障的完整性，从而恢复了肾脏功能和尿酸代谢。MFPP 被证明具有作为一种治疗策略的潜力，可以纳入饮食干预以缓解 HUA。
