Carlborg L, Lindoff C, Hellman A
Department of Gynaecology, Länssjukhuset, Halmstad, Sweden.
Eur J Anaesthesiol. 1987 Jul;4(4):241-7.
A double-blind study was performed in 63 patients to compare diclofenac (a non-steroidal anti-inflammatory drug), pethidine and placebo with regard to efficacy and tolerability in the treatment of pain after abdominal hysterectomy. The compounds were injected post-operatively and the duration of pain relief was chosen as the parameter of efficacy. Pain intensity was measured on a visual analogue scale by the patient and according to a six-point scale by the investigator. Diclofenac gave significantly longer pain relief than pethidine or placebo. Few side-effects were reported after diclofenac and placebo, and post-operative bowel paralysis tended to be shorter with diclofenac.
对63例患者进行了一项双盲研究，以比较双氯芬酸（一种非甾体抗炎药）、哌替啶和安慰剂在腹部子宫切除术后疼痛治疗中的疗效和耐受性。这些药物在术后注射，将疼痛缓解的持续时间作为疗效参数。患者通过视觉模拟量表测量疼痛强度，研究者则根据六点量表进行测量。双氯芬酸的止痛时间明显长于哌替啶或安慰剂。使用双氯芬酸和安慰剂后报告的副作用较少，且使用双氯芬酸后术后肠麻痹往往持续时间较短。
