Talja M, Kivisaari L, Mäkinen J, Lehtonen T
Second Department of Surgery, Helsinki University Central Hospital, Finland.
Eur Urol. 1987;13(4):259-63. doi: 10.1159/000472791.
The management of urethral strictures is a challenge for surgery. In the present study the value of tunica vaginalis tissue for urethroplasty was investigated. 30 male rabbits were divided into two groups. In group I (11 animals) a urethral defect was covered with a tunica vaginalis patch (n = 6) or was left uncovered (n = 5). In group II (19 animals) a preoperative urethral stricture was induced by electrocoagulation through a urethroscope. The strictured urethra was plastied with tunica vaginalis (n = 9) or preputial (n = 10) patches. The results were analyzed after a period of 2 weeks to 5 months with radiographic, macroscopic and microscopic methods. The tunica vaginalis graft showed its superiority over the preputial graft: only 1 postoperative short stricture from 15 plasties (6 normal and 9 strictured urethrae) was found in the plastied group, whereas 2 strictures from 10 plasties were seen in the preputial patch group. In the urethral defect group, strictures were seen in 2 of 5 animals. The mesenchymal tunica vaginalis epithelium was covered with thin transitiocellular-like epithelium resembling transitiocellular layers. The present study supports the earlier findings on the use of tunica vaginalis tissue in urethroplasty.
尿道狭窄的治疗是外科手术的一项挑战。在本研究中，对睾丸鞘膜组织在尿道成形术中的价值进行了研究。30只雄性兔子被分为两组。在第一组（11只动物）中，尿道缺损用睾丸鞘膜补片覆盖（n = 6）或不覆盖（n = 5）。在第二组（19只动物）中，通过尿道镜电凝诱导术前尿道狭窄。狭窄的尿道用睾丸鞘膜（n = 9）或包皮（n = 10）补片进行整形。在2周至5个月的时间段后，用放射学、宏观和微观方法对结果进行分析。睾丸鞘膜移植物显示出优于包皮移植物：在整形组中，15例整形（6例正常尿道和9例狭窄尿道）术后仅发现1例短期狭窄，而在包皮补片组中，10例整形中有2例出现狭窄。在尿道缺损组中，5只动物中有2只出现狭窄。睾丸鞘膜的间充质上皮覆盖着类似于移行细胞层的薄的移行细胞样上皮。本研究支持了早期关于睾丸鞘膜组织在尿道成形术中应用的研究结果。
