利血平诱导豚鼠心脏腺苷酸环化酶制剂超敏反应。

Reserpine-induced supersensitivity in adenylate cyclase preparations from guinea-pig heart.

作者信息

Cros G H, McNeill J H

机构信息

Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.

出版信息

Eur J Pharmacol. 1987 Jul 2;139(1):97-101. doi: 10.1016/0014-2999(87)90502-4.

DOI:10.1016/0014-2999(87)90502-4

PMID:3653243

Abstract

The effects of a reserpine treatment inducing supersensitivity to the cardiac effects of agonists (2.5 mg/kg per day for 2 days) was studied on guinea-pig cardiac adenylate cyclase (AC) activity. Reserpine treatment had no effect on basal or Gpp(NH)p (10(-7) M)-stimulated activities. Histamine (2 X 10(-6) and 10(-4) M) stimulation of guinea-pig AC was not influenced by the reserpine treatment. Epinephrine stimulation of AC was affected by reserpine and was characterized by an upward shift of the epinephrine dose-response curve with no change in the epinephrine EC50. The results indicate that the enhancement of cyclic AMP production is an important factor in the reserpine-induced cardiac supersensitivity to beta-adrenoceptor agonists.

摘要

研究了利血平治疗（每天2.5mg/kg，持续2天）诱导对激动剂心脏效应超敏反应对豚鼠心脏腺苷酸环化酶（AC）活性的影响。利血平治疗对基础活性或Gpp(NH)p（10^(-7)M）刺激的活性没有影响。组胺（2×10^(-6)和10^(-4)M）对豚鼠AC的刺激不受利血平治疗的影响。肾上腺素对AC的刺激受利血平影响，其特征是肾上腺素剂量反应曲线向上移位，而肾上腺素EC50不变。结果表明，环磷酸腺苷生成的增强是利血平诱导的心脏对β-肾上腺素能激动剂超敏反应的一个重要因素。