Nandula Savitri Aninditha, Boddepalli Chinmayi Sree, Gutlapalli Sai Dheeraj, Lavu Vamsi Krishna, Abdelwahab Mohamed Abdelwahab Rana, Huang Ruimin, Potla Shanthi, Bhalla Sushen, AlQabandi Yousif, Balani Prachi
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Dermatology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2022 Nov 14;14(11):e31482. doi: 10.7759/cureus.31482. eCollection 2022 Nov.
A frequent complication in kidney transplantation is post-transplant diabetes mellitus (PTDM). The primary goal of this study is to review the risk factors and preventive methods and compare the different available anti-diabetic medications for the management of PTDM. We searched databases like Pubmed and Google Scholar for related articles using specific terms and phrases. Following a thorough investigation, we applied the inclusion and exclusion criteria and completed a quality assessment. Modifiable risk factors have a significant role in the development of PTDM. The combinations of immunosuppressive treatment tacrolimus (TAC), cyclosporine A (CYC), and everolimus (EVL), steroids increase the incidence of PTDM significantly. Insulin is the most effective treatment for PTDM in the early transplant period; however, oral anti-diabetic medications look promising. Further clinical trials are required to determine the optimum treatment method for reducing the occurrence of PTDM and treating the existing condition with novel anti-hyperglycemic medications.
肾移植中常见的并发症是移植后糖尿病（PTDM）。本研究的主要目的是回顾其危险因素和预防方法，并比较用于治疗PTDM的不同抗糖尿病药物。我们使用特定的术语和短语在PubMed和谷歌学术等数据库中搜索相关文章。经过全面调查，我们应用了纳入和排除标准并完成了质量评估。可改变的危险因素在PTDM的发生中起重要作用。免疫抑制治疗他克莫司（TAC）、环孢素A（CYC）和依维莫司（EVL）与类固醇的联合使用显著增加了PTDM的发生率。胰岛素是移植早期治疗PTDM最有效的方法；然而，口服抗糖尿病药物看起来很有前景。需要进一步的临床试验来确定减少PTDM发生并使用新型降糖药物治疗现有疾病的最佳治疗方法。
