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预防移植后糖尿病:迈向个性化方法。

Prevention of Post-Transplant Diabetes Mellitus: Towards a Personalized Approach.

作者信息

Ducloux Didier, Courivaud Cécile

机构信息

CHU Besançon, Department of Nephrology, Dialysis and Renal Transplantation, Federation Hospitalo-Universitaire INCREASE, 25000 Besançon, France.

UMR RIGHT 1098, INSERM-EFS-UFC, 1 Bd Fleming, 25000 Besançon, France.

出版信息

J Pers Med. 2022 Jan 15;12(1):116. doi: 10.3390/jpm12010116.

Abstract

Post-transplant diabetes is a frequent complication after transplantation. Moreover, patients suffering from post-transplant diabetes have increased cardiovascular morbidity and reduced survival. Pathogenesis mainly involves beta-cell dysfunction in presence of insulin resistance. Both pre- and post-transplant risk factors are well-described, and some of them may be corrected or prevented. However, the frequency of post-transplant diabetes has not decreased in recent years. We realized a critical appraisal of preventive measures to reduce post-transplant diabetes.

摘要

移植后糖尿病是移植后常见的并发症。此外,患有移植后糖尿病的患者心血管发病率增加,生存率降低。发病机制主要涉及存在胰岛素抵抗时的β细胞功能障碍。移植前和移植后的危险因素均有详尽描述,其中一些危险因素可以得到纠正或预防。然而,近年来移植后糖尿病的发生率并未下降。我们对降低移植后糖尿病的预防措施进行了批判性评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5bc/8778007/247beaa63fb6/jpm-12-00116-g001.jpg

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