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新冠病毒治疗导致的肝损伤——我们了解多少？

Liver injury induced by COVID 19 treatment - what do we know?

机构信息

Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.

出版信息

World J Gastroenterol. 2022 Dec 7;28(45):6314-6327. doi: 10.3748/wjg.v28.i45.6314.

DOI:10.3748/wjg.v28.i45.6314
PMID:36533104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9753058/
Abstract

The severity of coronavirus disease 2019 (COVID-19) may be correlated with the risk of liver injury development. An increasing number of studies indicate that degrees of hepatotoxicity have been associated with using some medications in the management of COVID-19 patients. However, limited studies have systematically investigated the evidence of drug-induced liver injury (DILI) in COVID-19 patients. An increasing number of studies indicate that degrees of hepatotoxicity have been associated with using some of these medications in the management of COVID-19 patients. Significantly, it was relieved after the cessation of these agents. However, to our knowledge, no studies have systematically investigated the evidence of DILI in COVID-19 patients. In this review, we discussed the association between hepatotoxicity in COVID-19 patients and the drugs used in these patients and possible mechanisms of hepatotoxicity. The currently available evidence on the association of different therapeutic agents with hepatotoxicity in COVID-19 patient was systematically reviewed.

摘要

新型冠状病毒病 2019（COVID-19）的严重程度可能与肝损伤发展的风险相关。越来越多的研究表明，某些药物在 COVID-19 患者管理中的肝毒性程度与肝毒性有关。然而，有限的研究系统地调查了 COVID-19 患者药物性肝损伤（DILI）的证据。越来越多的研究表明，某些药物在 COVID-19 患者管理中的肝毒性程度与这些药物的使用有关。值得注意的是，在停止使用这些药物后，肝毒性明显得到缓解。然而，据我们所知，尚无研究系统地调查 COVID-19 患者 DILI 的证据。在这篇综述中，我们讨论了 COVID-19 患者的肝毒性与这些患者使用的药物之间的关系以及肝毒性的可能机制。系统地回顾了 COVID-19 患者不同治疗药物与肝毒性之间关联的现有证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c19/9753058/17d8a9aeb042/WJG-28-6314-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c19/9753058/17d8a9aeb042/WJG-28-6314-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c19/9753058/17d8a9aeb042/WJG-28-6314-g001.jpg

相似文献

[1]
Liver injury induced by COVID 19 treatment - what do we know?

World J Gastroenterol. 2022-12-7

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Multiorgan Involvement and Particularly Liver Injury in Long COVID: A Narrative Review.

Life (Basel). 2025-8-19

[2]
COVID-19 and Its Effects on the Hepatobiliary System: A Literature Review.

Cureus. 2025-3-7

[3]
Recent advances in COVID-19-induced liver injury: causes, diagnosis, and management.

Inflammopharmacology. 2024-10

[4]
Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.

Zool Res. 2024-5-18

[5]
Age-dependent immune responses in COVID-19-mediated liver injury: focus on cytokines.

Front Endocrinol (Lausanne). 2023

[6]
Research landscape on COVID-19 and liver dysfunction: A bibliometric analysis.

World J Gastroenterol. 2023-7-21

[7]
COVID-19: Has the Liver Been Spared?

Int J Mol Sci. 2023-1-6

本文引用的文献

[1]
Liver injury after SARS-CoV-2 vaccination: Features of immune-mediated hepatitis, role of corticosteroid therapy and outcome.

Hepatology. 2022-12

[2]
COVID-19: Gastrointestinal manifestations, liver injury and recommendations.

World J Clin Cases. 2022-2-6

[3]
Mechanism of SARS-CoV-2 Invasion into the Liver and Hepatic Injury in Patients with COVID-19.

Mediterr J Hematol Infect Dis. 2022-1-1

[4]
Drug-induced liver injury and COVID-19: A review for clinical practice.

World J Hepatol. 2021-9-27

[5]
Janus kinase (JAK)-inhibitors and coronavirus disease 2019 (Covid-19) outcomes: a systematic review and meta-analysis.

Expert Rev Anti Infect Ther. 2022-3

[6]
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial.

Lancet Respir Med. 2021-12

[7]
COVID-19 infection and liver injury: Clinical features, biomarkers, potential mechanisms, treatment, and management challenges.

World J Clin Cases. 2021-8-6

[8]
Drug-Induced Liver Injury After COVID-19 Vaccine.

Cureus. 2021-7-19

[9]
Elevated Plasma Fibrinogen Is Associated With Excessive Inflammation and Disease Severity in COVID-19 Patients.

Front Cell Infect Microbiol. 2021

[10]
Drug-induced liver injury associated with lopinavir-ritonavir in patients with COVID-19: a disproportionality analysis of U.S. food and drug administration adverse event reporting system (FAERS) data.

Int J Clin Pharm. 2021-8

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