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环状Vps41正向调节突触素，其过表达可改善衰老小鼠的记忆能力。

Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice.

作者信息

Li Yibo, Wang Hongfang, Gao Yanjing, Zhang Runjiao, Liu Qing, Xie Wenmeng, Liu Ziyu, Geng Dandan, Wang Lei

机构信息

Department of Human Anatomy, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang, Hebei, China.

The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang, Hebei, China.

出版信息

Front Mol Neurosci. 2022 Dec 2;15:1037912. doi: 10.3389/fnmol.2022.1037912. eCollection 2022.

DOI:10.3389/fnmol.2022.1037912
PMID:36533129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9756809/
Abstract

INTRODUCTION

Age is an established risk factor for neurodegenerative disorders. Aging-related cognitive decline is a common cause of memory impairment in aging individuals, in which hippocampal synaptic plasticity and hippocampus-dependent memory formation are damaged. Circular RNAs (circRNAs) have been reported in many cognitive disorders, but their role in aging-related memory impairment is unclear. In this study, we aimed to investigate the effects of circ-Vps41 on aging-related hippocampus-dependent memory impairment and explore the potential mechanisms. Here, D-galactose was used to produce a conventional aging model resulting in memory dysfunction.

RESULTS

Circ-Vps41 was significantly downregulated in D-galactose-induced aging and . The overexpression of circ-Vps41 could upregulate synaptophysin (Syp), thereby promoting the synaptic plasticity and alleviating cognitive impairment in aging mice. Mechanistically, we found that circ-Vps41 upregulated Syp expression by physically binding to miR-24-3p. Moreover, the miR-24-3p mimics reversed the circ-Vps41 overexpression-induced increase in Syp expression.

DISCUSSION

Overexpression of circ-Vps41 alleviated the synaptic plasticity and memory dysfunction via the miR-24-3p/Syp axis. These findings revealed circ-Vps41 regulatory network and provided new insights into its potential mechanisms for improving aging-related learning and memory impairment.

摘要

引言

年龄是神经退行性疾病公认的风险因素。与衰老相关的认知衰退是老年个体记忆障碍的常见原因，其中海马突触可塑性和海马依赖性记忆形成受损。环状RNA（circRNA）已在许多认知障碍中被报道，但其在与衰老相关的记忆障碍中的作用尚不清楚。在本研究中，我们旨在研究circ-Vps41对与衰老相关的海马依赖性记忆障碍的影响，并探索其潜在机制。在此，使用D-半乳糖建立导致记忆功能障碍的传统衰老模型。

结果

circ-Vps41在D-半乳糖诱导的衰老中显著下调。circ-Vps41的过表达可上调突触素（Syp），从而促进突触可塑性并减轻衰老小鼠的认知障碍。机制上，我们发现circ-Vps41通过与miR-24-3p物理结合上调Syp表达。此外，miR-24-3p模拟物逆转了circ-Vps41过表达诱导的Syp表达增加。

讨论

circ-Vps41的过表达通过miR-24-3p/Syp轴减轻了突触可塑性和记忆功能障碍。这些发现揭示了circ-Vps41调控网络，并为其改善与衰老相关的学习和记忆障碍的潜在机制提供了新见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/5c908a1eb570/fnmol-15-1037912-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/016388aaad1b/fnmol-15-1037912-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/3bd3679fe0e2/fnmol-15-1037912-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/b4e4bbdbe33f/fnmol-15-1037912-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/351863765202/fnmol-15-1037912-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/0b1fa7f569db/fnmol-15-1037912-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/414fbfb46ff2/fnmol-15-1037912-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/5c908a1eb570/fnmol-15-1037912-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/016388aaad1b/fnmol-15-1037912-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/3bd3679fe0e2/fnmol-15-1037912-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/b4e4bbdbe33f/fnmol-15-1037912-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/351863765202/fnmol-15-1037912-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/0b1fa7f569db/fnmol-15-1037912-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/414fbfb46ff2/fnmol-15-1037912-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6b/9756809/5c908a1eb570/fnmol-15-1037912-g007.jpg

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3
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R Soc Open Sci. 2024 Jun 12;11(6):240329. doi: 10.1098/rsos.240329. eCollection 2024 Jun.
4
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Sci Rep. 2024 Apr 4;14(1):7970. doi: 10.1038/s41598-024-57998-9.
5
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