肌肉减少症作为免疫检查点抑制剂在非小细胞肺癌中的疗效预测因素：一项荟萃分析。
Sarcopenia as a Determinant of the Efficacy of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer: A Meta-Analysis.
机构信息
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Soochow University, Suzhou, China.
出版信息
Nutr Cancer. 2023;75(2):685-695. doi: 10.1080/01635581.2022.2153879. Epub 2022 Dec 19.
OBJECTIVE
The impact of pre-immunotherapy sarcopenia in patients with non-small cell lung cancer (NSCLC) receiving immune checkpoint inhibitors (ICIs) is elusive. We performed a meta-analysis to investigate the association between sarcopenia and clinical outcomes of ICIs.
METHODS
PubMed, EMBASE, and the Cochrane Library were searched.
RESULTS
Thirteen clinical trials were selected. The 1,2-year overall survival rate was lower in the sarcopenia group (odds ratio (OR) = 2.44, 95% confidence interval (CI), 1.78-3.35, < 0.00001; OR = 1.60, 95% CI, 1.08-2.37, = 0.02), with = 34%, = 0.15, and = 41%, = 0.12. The 1,2-year progression-free survival (PFS) was the same (OR = 3.43, 95% CI, 1.86-6.33, < 0.0001; OR = 2.06, 95% CI, 1.19-3.58, < 0.0001), with = 31%, = 0.17 and 31%, = 0.17. Sarcopenia reduced the overall response rate (OR = 2.22, 95% CI, 1.01-4.84, = 0.02), with 56%, = 0.02, and disease control rate (OR = 3.15, 95% CI, 2.10-4.72, < 0.0001) with = 33%, = 0.18.
CONCLUSION
Pre-immunotherapy sarcopenia was associated with poor clinical outcomes in patients with advanced NSCLC who received ICIs.
目的
免疫检查点抑制剂（ICI）治疗的非小细胞肺癌（NSCLC）患者，其免疫治疗前肌肉减少症的影响难以捉摸。我们进行了一项荟萃分析，以研究肌肉减少症与 ICI 临床结局之间的关系。
方法
检索了 PubMed、EMBASE 和 Cochrane 图书馆。
结果
选择了 13 项临床试验。在肌肉减少症组中，1 年和 2 年的总生存率较低（优势比（OR）=2.44，95%置信区间（CI），1.78-3.35， < 0.00001；OR = 1.60，95%CI，1.08-2.37， = 0.02）， = 34%， = 0.15， = 41%， = 0.12。1 年和 2 年的无进展生存期（PFS）相同（OR = 3.43，95%CI，1.86-6.33， < 0.0001；OR = 2.06，95%CI，1.19-3.58， < 0.0001）， = 31%， = 0.17 和 31%， = 0.17。肌肉减少症降低了总缓解率（OR = 2.22，95%CI，1.01-4.84， = 0.02）， = 56%， = 0.02，以及疾病控制率（OR = 3.15，95%CI，2.10-4.72， < 0.0001）， = 33%， = 0.18。
结论
接受 ICI 治疗的晚期 NSCLC 患者，免疫治疗前肌肉减少症与临床结局不良相关。
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