Sparatore A, Veronese M, Sparatore F
Istituto di Chimica Biologica, i Cattedra di Chimica e Propedeutica Biochimica, Universita di Genova.
Farmaco Sci. 1987 Mar;42(3):159-74. doi: 10.1002/chin.198745342.
Thirty quinolizidinyl derivatives, together with two dialkylaminoalkyl analogues, were tested at concentration up to 160 mg/l for antimicrobial activity against 17 microrganisms, including gram-positive and gram-negative strains, Mycobac, tuberculosis, Trichom, vaginalis, fungi and yeasts. The most common activity found is that against Mycobac, tuberculosis, followed by that against gram-positive strains; several compounds [(I a), (I b), (I c), (II a), (III a), (VIII e), (XIX e), (XXI e)] exhibit a good or a very high level of activity. Concerning the gram-negative bacteria, activity is found only against Escherichia coli and is random and usually slight, as is that against fungi, yeasts and protozoa. Compounds (I a), (III a) and (XXI e) are of interest for their high activity and for their broad spectrum of activity, while compound (X e) is peculiar for its selectivity against Mycobac. tuberculosis.
测试了30种喹诺里西啶衍生物以及两种二烷基氨基烷基类似物，浓度高达160mg/l，以检测其对17种微生物的抗菌活性，这些微生物包括革兰氏阳性和革兰氏阴性菌株、结核分枝杆菌、阴道毛滴虫、真菌和酵母菌。最常见的活性是对结核分枝杆菌的活性，其次是对革兰氏阳性菌株的活性；几种化合物[（I a）、（I b）、（I c）、（II a）、（III a）、（VIII e）、（XIX e）、（XXI e）]表现出良好或非常高的活性水平。对于革兰氏阴性菌，仅发现对大肠杆菌有活性，且是随机的，通常很微弱，对真菌、酵母菌和原生动物的活性也是如此。化合物（I a）、（III a）和（XXI e）因其高活性和广谱活性而受到关注，而化合物（X e）因其对结核分枝杆菌的选择性而独特。
