Hegewisch-Becker Susanna, Kratz-Albers Karsten, Wierecky Jan, Gerhardt Steffen, Reschke Daniel, Borchardt Jens, Reichelt Ralf, Friedrich Felix Walter
Onkologische Schwerpunktpraxis, Facharztzentrum Eppendorf, Hamburg, Germany.
Gemeinschaftspraxis für Hämatologie und Onkologie, Münster, Germany.
Future Oncol. 2022 Dec 19. doi: 10.2217/fon-2022-0141.
Pancreatic cancer is one of the most aggressive cancers, with comparatively poor outcomes despite the use of multiagent conventional chemotherapy regimens. Real-world data from clinical practice are still rare but are the basis for understanding and improving the current standard of care. In this multi-institutional retrospective analysis of 24 office-based oncology practices in Germany, the authors documented 1786 pancreatic cancer patients who received systemic treatment between April 2017 and June 2021. The authors' analysis showed that results from recent clinical studies are promptly incorporated into practice. It was striking that, during the analyzed period, the use of platinum-based therapy regimens in adjuvant and palliative first-line therapy increased predominantly in younger patients (<70 years).
胰腺癌是侵袭性最强的癌症之一,尽管使用了多药联合的传统化疗方案,但其治疗效果相对较差。来自临床实践的真实世界数据仍然很少,但却是理解和改善当前护理标准的基础。在这项对德国24家门诊肿瘤学实践机构进行的多机构回顾性分析中,作者记录了2017年4月至2021年6月期间接受全身治疗的1786例胰腺癌患者。作者的分析表明,近期临床研究的结果迅速应用于实践。令人惊讶的是,在分析期间,铂类治疗方案在辅助和姑息一线治疗中的使用主要在较年轻患者(<70岁)中增加。