Winkler Julia Katharina, Haenssle Holger Andreas, Uhlmann Lorenz, Schweizer-Rick Anissa, Fink Christine
Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
Novartis Pharma GmbH, Basel, Switzerland.
Dermatol Pract Concept. 2022 Oct 1;12(4):e2022164. doi: 10.5826/dpc.1204a164. eCollection 2022 Nov.
UV irradiation of nevi induces transient melanocytic activation with dermoscopic and histological changes.
We investigated whether UV irradiation of nevi may influence electrical impedance spectroscopy (EIS) or convolution neural networks (CNN).
Prospective, controlled trial in 50 patients undergoing phototherapy (selective UV phototherapy (SUP), UVA1, SUP/UVA1, or PUVA). EIS (Nevisense, SciBase AB) and CNN scores (Moleanalyzer-Pro, FotoFinder Systems) of nevi were assessed before (V1) and after UV irradiation (V2). One nevus (nevus) was exposed to UV light, another UV-shielded (nevus-).
There were no significant differences in EIS scores of nevus before (2.99 [2.51-3.47]) and after irradiation (3.32 [2.86-3.78]; P = 0.163), which was on average 13.28 (range 4-47) days later. Similarly, UV-shielded nevus- did not show significant changes of EIS scores (V1: 2.65 [2.19-3.11]), V2: 2.92 [2.50-3.34]; P = 0.094). Subgroup analysis by irradiation revealed a significant increase of EIS scores of nevus (V1: 2.69 [2.21-3.16], V2: 3.23 [2.72-3.73]; P = 0.044) and nevus- (V1: 2.57 [2.07-3.07], V2: 3.03 [2.48-3.57]; P = 0.033) for patients receiving SUP. In contrast, CNN scores of nevus (P = 0.995) and nevus- (P = 0.352) showed no significant differences before and after phototherapy.
For the tested EIS system increased EIS scores were found in nevi exposed to SUP. In contrast, CNN results were more robust against UV exposure.
对痣进行紫外线照射会引起短暂的黑素细胞活化，并伴有皮肤镜和组织学变化。
我们研究了对痣进行紫外线照射是否会影响电阻抗光谱（EIS）或卷积神经网络（CNN）。
对50例接受光疗（选择性紫外线光疗（SUP）、UVA1、SUP/UVA1或补骨脂素紫外线A光化学疗法（PUVA））的患者进行前瞻性对照试验。在紫外线照射前（V1）和照射后（V2）评估痣的EIS（Nevisense，SciBase AB）和CNN评分（Moleanalyzer-Pro，FotoFinder Systems）。一颗痣（痣）暴露于紫外线下，另一颗用紫外线防护（痣-）。
照射前（2.99[2.51-3.47]）和照射后（3.32[2.86-3.78]；P=0.163）痣的EIS评分无显著差异，平均照射时间为13.28天（范围4-47天）。同样，紫外线防护的痣-的EIS评分也没有显著变化（V1：2.65[2.19-3.11]），V2：2.92[2.50-3.34]；P=0.094）。按照射方式进行的亚组分析显示，接受SUP的患者痣（V1：2.69[2.21-3.16]，V2：3.23[2.72-3.73]；P=0.044）和痣-（V1：2.57[2.07-3.07]，V2：3.03[2.48-3.57]；P=0.033）的EIS评分显著增加。相比之下，痣（P=0.995）和痣-（P=0.352）的CNN评分在光疗前后无显著差异。
对于测试的EIS系统，暴露于SUP的痣的EIS评分增加。相比之下，CNN结果对紫外线暴露更具稳健性。
