Hofmann-Wellenhof R, Soyer H P, Wolf I H, Smolle J, Reischle S, Rieger E, Kenet R O, Wolf P, Kerl H
Department of Dermatology, University of Graz, Austria.
Arch Dermatol. 1998 Jul;134(7):845-50. doi: 10.1001/archderm.134.7.845.
UV radiation can lead to clinical, histological, and ultrastructural changes in melanocytic nevi. In this study, we investigated whether exposure to 2 minimal erythema doses of UV radiation induces changes in the dermoscopic image of acquired melanocytic nevi.
Fifteen melanocytic nevi were exposed to 2 minimal erythema doses of UV radiation. Differences in dermoscopic parameters (asymmetry, border, erythema, and telangiectasias in the nevus; pigmentation; hypopigmented areas; presence, regularity, and sharpness of pigment network; and brown-black globules) in digital dermoscopic images taken before and 3, 7, 14, and 28 days after UV irradiation were scored. Three days after UV irradiation, the borders of nevi were more faded (P<.02), the nevi were darker brown (P<.02), the hypopigmented areas were smaller (P<.02), and the pigment network structures were more faded (P<.007) and less prominent (P<.02) than before UV irradiation. Seven days after UV irradiation, pigmented globules have also grown (P<.05). After 28 days, all parameters, except hypopigmented areas, were essentially the same as before UV irradiation.
UV irradiation of melanocytic nevi with 2 minimal erythema doses induces transient changes in their dermoscopic appearance that are sometimes suggestive of malignant melanoma.
紫外线辐射可导致黑素细胞痣出现临床、组织学及超微结构变化。在本研究中，我们调查了暴露于2个最小红斑量的紫外线辐射是否会引起获得性黑素细胞痣皮肤镜图像的改变。
15个黑素细胞痣暴露于2个最小红斑量的紫外线辐射。对紫外线照射前以及照射后3天、7天、14天和28天所拍摄的数字皮肤镜图像中的皮肤镜参数（痣的不对称性、边界、红斑和毛细血管扩张；色素沉着；色素减退区域；色素网的存在、规则性和清晰度；以及棕黑色小球）进行评分。紫外线照射3天后，痣的边界更模糊（P<0.02），痣呈深褐色（P<0.02），色素减退区域更小（P<0.02），色素网结构比紫外线照射前更模糊（P<0.007）且更不明显（P<0.02）。紫外线照射7天后，色素小球也增大了（P<0.05）。28天后，除色素减退区域外，所有参数基本与紫外线照射前相同。
用2个最小红斑量对黑素细胞痣进行紫外线照射会引起其皮肤镜外观的短暂变化，这些变化有时提示恶性黑色素瘤。
