Bae Kyeore, Lamoury Gillian, Carroll Susan, Morgia Marita, Lim Stephanie, Baron-Hay Sally, Shin In-Soo, Park So-Jung, Oh Byeongsang
Integrative Cancer Center, Doban Hospital, Seoul, 03170, Republic of Korea; Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, 2065, Australia.
Northern Sydney Cancer Centre, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, 2065, Australia; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, 2006, Australia.
Crit Rev Oncol Hematol. 2023 Jan;181:103898. doi: 10.1016/j.critrevonc.2022.103898. Epub 2022 Dec 16.
Aromatase inhibitor-induced arthralgia (AIA) contributes to poor adherence of aromatase inhibitor therapies in patients with breast cancer. A systematic review using network meta-analysis (NMA) was conducted to examine the clinical effectiveness of multiple therapies and rank probabilities for the management of AIA. Randomized controlled trials (RCTs) assessing treatments for AIA in postmenopausal women with stage 0-III hormone receptor-positive breast cancer were searched from inception to October 2021. The main NMA involved 1516 participants from 17 RCTs. Acupuncture was the highest ranked intervention to improve pain intensity followed by sham acupuncture, multicomponent herbal medicine, exercise, duloxetine, vitamin D, omega-3 fatty acids, physical therapy, testosterone, and inactive controls. Single natural products were inferior to controls. The current review provides new insights into the management of AIA in breast cancer survivors for increased survival and can be utilized to make evidence-based decisions regarding treatment.
芳香化酶抑制剂所致关节痛（AIA）导致乳腺癌患者对芳香化酶抑制剂治疗的依从性较差。进行了一项采用网状Meta分析（NMA）的系统评价，以检验多种治疗方法的临床疗效，并对AIA管理的可能性进行排序。检索了从开始到2021年10月评估0-III期激素受体阳性绝经后乳腺癌女性AIA治疗方法的随机对照试验（RCT）。主要的NMA纳入了来自17项RCT的1516名参与者。针灸是改善疼痛强度排名最高的干预措施，其次是假针灸、多成分草药、运动、度洛西汀、维生素D、ω-3脂肪酸、物理治疗、睾酮和无活性对照。单一天然产物不如对照。本综述为提高乳腺癌幸存者的生存率提供了关于AIA管理的新见解，可用于做出基于证据的治疗决策。
