Shrestha Sadina, Dhakal Bishal, Sapkota Sachin, Pathak Bishnu Deep, Dhakal Binaya, Mainali Saugat, Lamicchane Saurav, Simkhada Nabin, Ale Magar Priajan, Dawadi Sagun, Phuyal Subash
Upendra Devkota Memorial National Institute of Neurological and Allied Sciences, Department of Neuroradiology, Kathmandu, Nepal.
Nepalese Army Institute of Health and Sciences, Department of Internal Medicine, Kathmandu, Nepal.
Ann Med Surg (Lond). 2022 Nov 19;84:104953. doi: 10.1016/j.amsu.2022.104953. eCollection 2022 Dec.
To study the relationship of size of corpus callosum with white matter changes in the elderly population.
This was a retrospective analytical cross-sectional study. The relationship between the corpus callosum and white matter changes was studied using the magnetic resonance imaging technique, where white matter changes were graded based on Fazekas grading. The Spearman rank order correlation was used to assess the relationship between the size of corpus callosum and white matter changes.
The whole corpus callosum (ρ = 0.165, p = 0.044) and rostrum (ρ = -0.232, p = 0.004) was significantly correlated with white matter changes based on Fazekas severity grading. Similarly, in bivariate regression analysis, white matter changes were strongly correlated with rostrum (standardized β-coefficient = -0.186, p = 0.023). While taking gender in sub-group analysis, white matter changes were significantly correlated with rostrum (ρ = -0.252, p = 0.021) and splenium (ρ = -0.229, p = 0.036) in male and with rostrum (ρ = -0.245, p = 0.048) only in female groups.
Corpus callosum size is associated with white matter changes in the elderly population. This association can give insight into the neuropathology of diseases involving the central nervous system.
研究老年人群胼胝体大小与白质变化的关系。
这是一项回顾性分析横断面研究。使用磁共振成像技术研究胼胝体与白质变化之间的关系，其中白质变化根据 Fazekas 分级进行分级。采用 Spearman 等级相关分析评估胼胝体大小与白质变化之间的关系。
根据 Fazekas 严重程度分级，整个胼胝体（ρ = 0.165，p = 0.044）和嘴部（ρ = -0.232，p = 0.004）与白质变化显著相关。同样，在双变量回归分析中，白质变化与嘴部密切相关（标准化β系数 = -0.186，p = 0.023）。在亚组分析中考虑性别时，男性中白质变化与嘴部（ρ = -0.252，p = 0.021）和压部（ρ = -0.229，p = 0.036）显著相关，而女性组中仅与嘴部（ρ = -0.245，p = 0.048）相关。
胼胝体大小与老年人群白质变化有关。这种关联可为涉及中枢神经系统疾病的神经病理学研究提供线索。
