Vermersch P, Roche J, Hamon M, Daems-Monpeurt C, Pruvo J P, Dewailly P, Petit H
Department of Neurology, CHU de Lille, France.
J Neurol. 1996 Mar;243(3):231-4. doi: 10.1007/BF00868519.
We have previously demonstrated with MRI that as well as marked white matter involvement in late-onset Alzheimer's disease (AD), atrophy of the corpus callosum may also be present. This finding prompted us to study possible correlations between atrophy of the corpus callosum and white matter hyperintensity (WMH) and between white matter lesions and the severity of the disease. We compared the corpus callosum and white matter lesions on MRI from 15 AD patients and 15 controls. The white matter lesions were scored according to the Scheltens' rating scale. We found a significant reduction of the area of the corpus callosum and more severe white matter lesions in AD patients than in controls. Both atrophy of the corpus callosum and the severity of lesions depended mainly on the diagnosis of senile dementia of the Alzheimer type and on age but not on the diagnosis of presenile AD. We demonstrated a negative correlation between white matter lesions scores and areas of corpus callosum in AD patients and no correlation between the white matter lesions and the severity of the disease. We demonstrated that white matter lesions including WMH and atrophy of the corpus callosum are more frequent in AD than in controls. The predominance of white matter lesions in senile AD may be explained by the combination of aging and disease processes.
我们之前通过磁共振成像（MRI）证明，除了迟发性阿尔茨海默病（AD）中明显的白质受累外，胼胝体萎缩也可能存在。这一发现促使我们研究胼胝体萎缩与白质高信号（WMH）之间以及白质病变与疾病严重程度之间可能存在的相关性。我们比较了15例AD患者和15例对照者MRI上的胼胝体和白质病变情况。白质病变根据Scheltens评分量表进行评分。我们发现，与对照者相比，AD患者的胼胝体面积显著减小，白质病变更严重。胼胝体萎缩和病变严重程度主要取决于阿尔茨海默型老年痴呆的诊断及年龄，而非早老性AD的诊断。我们证明了AD患者白质病变评分与胼胝体面积之间呈负相关，且白质病变与疾病严重程度之间无相关性。我们证明，与对照者相比，AD患者中包括WMH和胼胝体萎缩在内的白质病变更为常见。老年AD中白质病变占优势可能是衰老和疾病过程共同作用的结果。
