Samad Muhammad Ammar, Mahboob Eman, Shafiq Aimen, Ur Rehman Mohammad Hassam, Sheikh Ayesha, Tharwani Zoaib Habib
Faculty of Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.
Ann Med Surg (Lond). 2022 Nov 9;84:104844. doi: 10.1016/j.amsu.2022.104844. eCollection 2022 Dec.
T cell lymphoma, a type of non-Hodgkin lymphomas is a rare form of malignancy with poor outcomes. TCLS are a heterogeneous group of lymphoid malignancies that occur in nodal and extranodal sites. There are two main types of TCLs namely T-lymphoblastic lymphoma/leukemia and Peripheral T-cell lymphomas classified based on clinical manifestations and cytogenetic mutations. The use of advance technology like karyotyping, fluorescent in situ hybridization (FISH), comparative genomic hybridization (CGH) has allowed us to study TCLs in detail and to observe a different biochemical change that occurs in different TCLs allowing us to classify and treat them differently. This review focuses on the different mutations occurring in different TCLs and how they help us distinguish one type from another.
T细胞淋巴瘤是一种非霍奇金淋巴瘤，是一种罕见的恶性肿瘤，预后较差。TCLS是一组异质性的淋巴恶性肿瘤，发生于淋巴结和结外部位。TCL主要有两种类型，即T淋巴母细胞淋巴瘤/白血病和外周T细胞淋巴瘤，它们是根据临床表现和细胞遗传学突变进行分类的。使用核型分析、荧光原位杂交（FISH）、比较基因组杂交（CGH）等先进技术，使我们能够详细研究TCL，并观察到不同TCL中发生的不同生化变化，从而使我们能够对它们进行分类并采取不同的治疗方法。本综述重点关注不同TCL中发生的不同突变，以及它们如何帮助我们区分不同类型的TCL。
