ETS 搏击俱乐部在微卫星增强子上。
ETS Fight Club on Microsatellite Enhancers.
机构信息
INSERM U1170, Gustave Roussy Cancer Campus, Université Paris Saclay, Program PEDIAC, Villejuif, France.
Equipe labellisée Ligue Nationale Contre le Cancer, Paris, France.
出版信息
Blood Cancer Discov. 2023 Jan 6;4(1):2-4. doi: 10.1158/2643-3230.BCD-22-0177.
Abstract
In this issue of Blood Cancer Discovery, Kodgule, Goldman, Monovichet al. cleverly analyzed the transcription regulatory elements to investigate why the second copy of ETV6 is often lost in ETV6::RUNX1-translocated in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). It turns out that ETV6 suppresses the enhancer activity of GGAA microsatellite repeats, preventing ERG from subverting them to activate aberrant oncogene transcription. See related article by Kodgule, Goldman, Monovich et al., p. 34 (5).
摘要
在本期《Blood Cancer Discovery》中，Kodgule、Goldman、Monovich 等人巧妙地分析了转录调控元件，以研究为什么 ETV6::RUNX1 易位的 B 细胞前体急性淋巴细胞白血病（BCP-ALL）中通常会丢失第二个 ETV6 拷贝。事实证明，ETV6 抑制 GGAA 微卫星重复序列的增强子活性，防止 ERG 颠覆它们以激活异常致癌基因转录。见 Kodgule、Goldman、Monovich 等人的相关文章，第 34 页（5）。
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2
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本文引用的文献
1
ETV6 Deficiency Unlocks ERG-Dependent Microsatellite Enhancers to Drive Aberrant Gene Activation in B-Lymphoblastic Leukemia.ETV6 缺失会解除 ERG 依赖性微卫星增强子对 B 淋巴母细胞白血病中异常基因激活的驱动作用。
Blood Cancer Discov. 2023 Jan 6;4(1):34-53. doi: 10.1158/2643-3230.BCD-21-0224.
2
PU.1-Dependent Enhancer Inhibition Separates Tet2-Deficient Hematopoiesis from Malignant Transformation.PU.1 依赖性增强子抑制将 Tet2 缺陷造血与恶性转化分离。
Blood Cancer Discov. 2022 Sep 6;3(5):444-467. doi: 10.1158/2643-3230.BCD-21-0226.
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Ewing's Sarcoma.尤因肉瘤
N Engl J Med. 2021 Jan 14;384(2):154-164. doi: 10.1056/NEJMra2028910.
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The ETS family of oncogenic transcription factors in solid tumours.固体肿瘤中 ETS 家族致癌转录因子。
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5
Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.嵌合蛋白EWSR1-FLI1通过GGAA微卫星调控尤文肉瘤易感基因EGR2。
Nat Genet. 2015 Sep;47(9):1073-8. doi: 10.1038/ng.3363. Epub 2015 Jul 27.
6
Germline mutations in ETV6 are associated with thrombocytopenia, red cell macrocytosis and predisposition to lymphoblastic leukemia.ETV6基因的种系突变与血小板减少、红细胞大细胞症以及淋巴细胞白血病易感性相关。
Nat Genet. 2015 May;47(5):535-538. doi: 10.1038/ng.3253. Epub 2015 Mar 25.
7
ETV6: a versatile player in leukemogenesis.ETV6：白血病发生过程中的多面手。
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8
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.TEL-AML1融合基因在儿童急性淋巴细胞白血病分子发病机制中的作用
Oncogene. 2004 May 24;23(24):4275-83. doi: 10.1038/sj.onc.1207672.
9
v-SRC specifically regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL (ETV6).v-SRC特异性调节TEL（ETV6）主要同种型的核质异位。
J Biol Chem. 2003 Oct 17;278(42):41316-25. doi: 10.1074/jbc.M306435200. Epub 2003 Jul 31.
10
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Cell. 1994 Jul 15;78(1):137-47. doi: 10.1016/0092-8674(94)90580-0.
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