The Department of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Department of Medical Records Statistics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
J Int Med Res. 2022 Dec;50(12):3000605221142401. doi: 10.1177/03000605221142401.
Pancreatic follicular dendritic cell sarcoma (FDCS) is a rare neoplasm with unclear pathological characteristics. In this study, we report one case of pancreatic FDCS and review published cases to summarize the characteristics and treatment of pancreatic FDCS. A man in his early 30 s was admitted for jaundice, abdominal fullness, and weight loss for 15 days. Computed tomography revealed a large capsule solid mass in the pancreatic head together with a dilated bile duct and enlarged retroperitoneal lymph nodes. Serum biochemistry revealed high total bilirubin levels (313.9 μmol/L) and normal tumor marker levels. Pancreatoduodenectomy was performed, but no chemotherapy was administrated at the patient's behest. The pathologic diagnosis was pancreatic FDCS infiltrating the duodenal seromuscular layer and common bile duct. The patient presented with liver metastasis 3 months after surgery and died 8 months after surgery from multiorgan failure. Pancreatic FDCS is a rare disease with high invasiveness. Our previous case exhibited paraneoplastic syndrome together with this disease, and further investigation is needed to confirm whether paraneoplastic syndrome is a typical syndrome of pancreatic FDCS.
胰腺滤泡树突状细胞肉瘤（FDCS）是一种罕见的肿瘤，其病理特征尚不清楚。本研究报告了 1 例胰腺 FDCS，并复习了已发表的病例，总结了胰腺 FDCS 的特征和治疗方法。一位 30 多岁的男性因黄疸、腹胀和消瘦 15 天入院。计算机断层扫描显示胰头部有一个大的包膜实性肿块，同时伴有胆管扩张和腹膜后淋巴结肿大。血清生化检查显示总胆红素水平升高（313.9 μmol/L），肿瘤标志物水平正常。患者接受了胰十二指肠切除术，但由于患者的要求，未进行化疗。病理诊断为胰腺 FDCS 浸润十二指肠浆膜肌层和胆总管。术后 3 个月患者出现肝转移，术后 8 个月因多器官功能衰竭死亡。胰腺 FDCS 是一种侵袭性很强的罕见疾病。我们之前的病例表现出副肿瘤综合征，需要进一步研究以确认副肿瘤综合征是否是胰腺 FDCS 的典型综合征。
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