Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga, SP, Brazil.
Center for the Study of Venoms and Venomous Animals (CEVAP), São Paulo State University (UNESP), Botucatu, SP, Brazil.
Rev Soc Bras Med Trop. 2022 Dec 16;55. doi: 10.1590/0037-8682-0323-2022. eCollection 2022.
Snake toxins are widely studied owing to their importance in snakebite accidents, a serious public health issue in tropical countries, and their broad therapeutic potential. Isolated fractions from venom produced by snakes of the genus Crotalus sp. present a wide variety of pharmacological uses such as antifungal, antiviral, antibacterial, and antitumor properties, among other therapeutic potentialities. Given the direct effect of this venom on tumor cells, isolation of its compounds is important for the characterization of its anticarcinogenic actions. Crotalus durissus terrificus venom and its toxins have been widely evaluated as potential candidates for the development of new antineoplastic therapies that are efficient against different tumor lines and cellular targets. This review highlights the venom toxins of this species, with a focus on their antineoplastic properties.
蛇毒因其在热带国家严重的公共卫生问题——蛇咬伤事故中的重要性，以及其广泛的治疗潜力而受到广泛研究。来自响尾蛇属(Crotalus sp.)蛇的毒液中分离得到的各个馏分具有多种药理作用，如抗真菌、抗病毒、抗菌和抗肿瘤特性等治疗潜力。鉴于这种毒液对肿瘤细胞的直接作用，分离其化合物对于表征其抗癌作用很重要。响尾蛇(Crotalus durissus terrificus)毒液及其毒素已被广泛评估为开发新的抗肿瘤疗法的潜在候选物，这些疗法对不同的肿瘤细胞系和细胞靶标有效。本文重点介绍了该物种的毒液毒素及其抗肿瘤特性。
