甲状腺功能减退对雄性小鼠海马体（CA1）、6区和17区锥体神经元核测量发育的影响。
Effects of hypothyroidism on the karyometric development of pyramidal neurons of the hippocampus (CA1), area 6 and area 17 in the male mouse.
作者信息
Pérez-Delgado M M, Ferres-Torres R, Castañeyra-Perdomo A, González-Hernández T
机构信息
Departamento de Anatomia, Facultad de Medicina, Universidad de La Laguna, Tenerife, Spain.
出版信息
J Anat. 1987 Feb;150:23-9.
Abstract
This study has examined the karyometric changes within pyramidal neurons of the hippocampus, motor area 6 and visual area 17 in a hypothyroid group of male mice treated with propylthiouracil, with or without interruption of treatment at the 35th postnatal day. Hypothyroidism resulted in decrease of nuclear size in the three areas before puberty and even after puberty in the hippocampus. Where the treatment was continued throughout the experimental period there was a progressive increase of nuclear size in both visual and motor areas.
摘要
本研究检测了用丙硫氧嘧啶处理的雄性甲状腺功能减退小鼠组中，海马体、运动区6和视觉区17的锥体神经元内的核测量变化，该处理在出生后第35天有无中断治疗。甲状腺功能减退导致青春期前这三个区域的细胞核大小减小，在海马体中甚至青春期后也是如此。在整个实验期间持续进行治疗的情况下，视觉区和运动区的细胞核大小都有逐渐增加。
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本文引用的文献
1
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Anat Rec. 1964 Oct;150:147-61. doi: 10.1002/ar.1091500206.
2
EFFECTS OF L-THYROXINE ON AMINO ACID INCORPORATION INTO PROTEIN IN MATURE AND IMMATURE RAT BRAIN.L-甲状腺素对成熟及未成熟大鼠脑内氨基酸掺入蛋白质的影响
J Neurochem. 1964 Apr;11:221-9. doi: 10.1111/j.1471-4159.1964.tb06134.x.
3
4
A method for the combined staining of cells and fibers in the nervous system.一种用于神经系统中细胞和纤维联合染色的方法。
J Neuropathol Exp Neurol. 1953 Oct;12(4):400-3. doi: 10.1097/00005072-195312040-00008.
5
The growth of non-pyramidal neurons in the visual cortex of the rat: a morphometric study.大鼠视皮层中非锥体神经元的生长：一项形态计量学研究。
Brain Res. 1980 Jul 14;193(2):373-82. doi: 10.1016/0006-8993(80)90171-7.
6
Reversible morphological alterations of cortical neurons in juvenile and adult hypothyroidism in the rat.大鼠幼年和成年甲状腺功能减退时皮质神经元的可逆性形态学改变
Brain Res. 1980 Mar 3;185(1):91-102. doi: 10.1016/0006-8993(80)90674-5.
7
Maturation of rat visual cortex. II. A combined Golgi-electron microscope study of pyramidal neurons.大鼠视皮层的发育。II. 锥体神经元的高尔基染色-电子显微镜联合研究
J Comp Neurol. 1981 Dec 20;203(4):555-73. doi: 10.1002/cne.902030402.
8
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