Department of Respiratory Disease and Critical Care Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Physiol Res. 2023 Mar 8;72(1):1-13. doi: 10.33549/physiolres.934971. Epub 2022 Dec 22.
Pyroptosis is a form of cell death associated with inflammation. In the maintenance of airway homeostasis, pyroptosis goes through activation and assembly of Inflammasome. The pyroptosis pathway is mediated by caspase which activates the pore-forming effect of substrate gasdermin family members. It eventually leads to lysis and release of the cell contents and then induces an inflammatory response. In this process, it participates in airway homeostasis regulation by affecting airway immunity, airway epithelial structure and airway microbiota. Therefore, we discussed the correlation between airway immunity, airway epithelial structure, airway microbiota and the mechanism of pyroptosis to describe the role of pyroptosis in airway homeostasis regulation which is of great significance for understanding the occurrence and treatment of airway inflammatory diseases.
细胞焦亡是一种与炎症相关的细胞死亡形式。在气道稳态的维持中，细胞焦亡通过炎症小体的激活和组装来实现。细胞焦亡途径是由半胱天冬酶介导的，其激活了gasdermin 家族成员的孔形成效应。最终导致细胞内容物的裂解和释放，从而诱导炎症反应。在此过程中，它通过影响气道免疫、气道上皮结构和气道微生物群来参与气道稳态调节。因此，我们讨论了气道免疫、气道上皮结构、气道微生物群与细胞焦亡机制之间的相关性，以描述细胞焦亡在气道稳态调节中的作用，这对于理解气道炎症性疾病的发生和治疗具有重要意义。
