Stem Cells, Canadian Blood Services, Ottawa, ON K2E 8A6, Canada.
Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
Curr Oncol. 2022 Dec 6;29(12):9572-9581. doi: 10.3390/curroncol29120752.
The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups. An analysis of distributed units is needed to assess the effectiveness of the bank to meet the needs of patients from different ethnic groups.
A descriptive analysis was performed on all cord blood units distributed from the CBS' CBB as of 30 June 2022.
Distribution of the first 60 units based on CBS' CBB inventory has been linear over time. A similar proportion of cord blood unit (CBU) recipients were pediatric or adult. More than half of the cord blood units (56.7%) were distributed to recipients outside of Canada, and CBUs were used to treat a broad range of hematologic and immune disorders. 43.3% of distributed CBUs were of non-Caucasian ethnicity and 18% were from donors self-reporting as multi-ethnic. The mean total nucleated cell counts and total CD34 cell counts were 1.9 ± 0.1 × 10 cells and 5.3 ± 0.5 × 10 CD34 cells, respectively. CD34 cells per kg (recipient weight) varied significantly between pediatric (age 0-4), adolescent (age 5-17) and adult recipients (age 18 and older) (3.1 ± 0.5, 1.4 ± 0.5 and 0.9 ± 0.07 × 10 CD34 cells/kg, respectively). HLA matching was 6/6 (15%), 5/6 (47%) or 4/6 (38%).
The CBS' CBB has facilitated the utilization of banked units for patients across a broad range of ages, geographic distribution, ethnicity, and diseases. Distributed units were well matched for HLA alleles and contained robust cell counts, reflecting a high-quality inventory with significant utility.
加拿大血液服务脐带血库（CBS CBB）的创建是为了改善不同种族群体患者的干细胞产品移植获取。需要对分发的单位进行分析，以评估该血库满足不同种族患者需求的效果。
对截至 2022 年 6 月 30 日，CBS CBB 分发的所有脐带血单位进行描述性分析。
根据 CBS CBB 库存，首批 60 个脐带血单位的分发呈线性增长。儿科或成年患者接受脐带血单位（CBU）的比例相似。超过一半的脐带血单位（56.7%）分发给加拿大境外的患者，CBU 用于治疗广泛的血液系统和免疫系统疾病。43.3%的分发 CBU 是非白种人，18%的 CBU 来自自我报告为多种族的供者。总核细胞计数和总 CD34 细胞计数的平均值分别为 1.9±0.1×10 个细胞和 5.3±0.5×10 CD34 细胞。儿童（0-4 岁）、青少年（5-17 岁）和成年（18 岁及以上）患者的 CD34 细胞/kg（受者体重）差异显著（分别为 3.1±0.5、1.4±0.5 和 0.9±0.07×10 CD34 细胞/kg）。HLA 配型为 6/6（15%）、5/6（47%）或 4/6（38%）。
CBS CBB 促进了对广泛年龄、地理分布、种族和疾病的患者使用库存单位。分发的单位在 HLA 等位基因上具有良好的匹配性，并且细胞计数丰富，反映了具有显著实用性的高质量库存。
