Watson A J, Gimenez L F, Klassen D K, Stout R L, Whelton A
Johns Hopkins Hospital, Baltimore, MD 21205.
J Clin Pharmacol. 1987 Aug;27(8):625-7. doi: 10.1002/j.1552-4604.1987.tb03076.x.
Calcium channel blocker therapy has proved protective in certain models of ischemic-induced acute renal failure. This effect may be related to the prevention of calcium influx into injured cells or by the vasodilatory effects of verapamil that may result in an improvement in renal blood flow. In the current study, the effect of verapamil treatment on the development of renal insufficiency and renal tissue calcium accumulation following aminoglycoside administration was investigated. The degree of functional damage and cortical tissue calcium accumulation after six or nine days of gentamicin administration (120 mg/kg body weight/day) was not significantly different in rats whose drinking water contained verapamil (10 mg/100 cc) than corresponding values in control animals. The tissue calcium accumulation correlated with the degree of reduction of creatinine clearance and probably reflects the extent of lethal tubular cell injury.
钙通道阻滞剂疗法已在某些缺血性急性肾衰竭模型中被证明具有保护作用。这种作用可能与防止钙流入受损细胞有关，或者与维拉帕米的血管舒张作用有关，后者可能会改善肾血流量。在本研究中，研究了维拉帕米治疗对氨基糖苷类药物给药后肾功能不全发展和肾组织钙积累的影响。给予庆大霉素（120mg/kg体重/天）6天或9天后，饮用水中含有维拉帕米（10mg/100cc）的大鼠的功能损害程度和皮质组织钙积累与对照动物的相应值相比无显著差异。组织钙积累与肌酐清除率降低程度相关，可能反映了致死性肾小管细胞损伤的程度。
